摘要
目的探讨分析注射用丹参多酚酸治疗缺血性脑卒中疗效与安全性。方法选取2018年1月—2019年12月于本院神经内科就诊的87例缺血性脑卒中患者作为研究对象,采用随机数表法分为对照组(42例)和观察组(45例)两组。对照组采用常规治疗,观察组采用常规治疗联合注射用丹参多酚酸治疗。评价两组患者疗程结束后的神经功能,统计其血液流变学指标改善情况及不良反应发生情况。结果观察组患者的NIHSS评分明显低于对照组,差异有统计学意义(P<0.05);观察组患者的全血黏度高切、全血黏度低切以及红细胞比积均低于对照组,差异有统计学意义(P<0.05);观察组患者与药物相关的不良反应发生率(2.22%)虽低于对照组(7.14%),但差异无统计学意义(P>0.05)。结论注射用丹参多酚酸治疗缺血性脑卒中有显著效果,血液流变学改善,安全性高,值得临床推广使用。
Objective To analyze the efficacy and safety of salvia miltiorrhiza polyphenolic acid for injection in the treatment of ischemic stroke.Methods 87 patients with ischemic stroke those admitted to our hospital during January 2018 and December 2019 were enrolled in the study and they were divided into two groups according to random number table method.42 cases in the control group received conventional treatment,and 45 cases in the observation group received conventional treatment combined with salvia polyphenolic acid for injection for treatment.After the treatment period,thenerve function of the two groups were evaluated,the improvement of blood rheology and occurrence of adverse effects of the two group were counted.Results The NIHSS score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).The high blood viscosity,low blood viscosity,and the hematocrit of the observation groupwas lower than the control group,the difference was statistically significant(P<0.05).The incidence of drug-related adverse reactions in the observation group was 2.22%and that in the control group was 7.14%,the difference between the two groups was not statistically significant(P>0.05).Conclusions Salvia polyphenolic acid for injection has a significant effect in treating ischemic stroke,hemorheology is improved,no adverse reactions occurred,and it is worth applying.
作者
陈肖
CHEN Xiao(Department of Neurology,people's hospital,Taikang county,Zhoukou,Henan,461400,China)
出处
《齐齐哈尔医学院学报》
2021年第4期303-305,共3页
Journal of Qiqihar Medical University
关键词
缺血性脑卒中
注射用丹参多酚酸
神经功能
血液流变学
不良反应
Ischemic stroke
Salvia polyphenolic acid for injection
Nerve function
Hemorheology
Adverse reaction
