摘要
倾向性评分方法是通过综合系列已知的可测量的协变量来模拟随机对照试验的随机化、提高组间的均衡性,进而降低混杂因素影响的一种分析策略。倾向性评分方法在观察性研究中应用越来越广泛。本文介绍了倾向性评分方法的原理、类型及其在观察性研究中的应用,同时对倾向性评分方法与多元回归、临床试验方法进行了比较。当前对倾向性评分方法的选择尚缺乏有效推荐,倾向性评分方法得到的结果与传统的回归分析、随机对照试验的结果也可能存在差异。
Propensity score methods belong to an analytical approach by incorporating the measured covariates and mimicking randomization to enhance the comparability between groups,hence reducing the impact of potential confounding in observational studies.Propensity score methods have been increasingly used in observational studies.This paper illustrates the principle and the methods based on the propensity score,in combination with its application in observational studies.It also compares results from propensity score methods with those from multivariable regression and randomized controlled trials.It was found that currently there has been a lack of recommendations for the selection of propensity score methods.Differences may exist when comparing results from propensity score methods with findings from typical regression analyses and randomized controlled trials.
作者
黎国威
张玲
陈裕明
陈耀龙
王肖杰
吴大嵘
LI Guowei;ZHANG Ling;CHEN Yuming;CHEN Yaolong;WANG Xiaojie;WU Darong(Center for Clinical Epidemiology and Methodology(CCEM),Guangdong Second Provincial General Hospital,Guangzhou 510317,P.R.China;School of Public Health,Capital Medical University,Beijing 100069,P.R.China;School of Public Health,Sun Yat-sen University,Guangzhou 510080,P.R.China;Evidence-Based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,P.R.China;Guangdong Provincial Hospital of Chinese Medicine,Guangdong Provincial Academy of Chinese Medical Sciences&2nd AffiliatedHospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2021年第4期469-474,共6页
Chinese Journal of Evidence-based Medicine
基金
国家重点研发计划项目(编号:2019YFC1709800、2019YFC1709802)。
关键词
倾向性评分
观察性研究
非随机化
Propensity score
Observational study
Non-randomization
