摘要
目的:调查妊娠期妇女甲状腺功能减退症(甲减)的发病情况,分析影响其发病的相关因素。方法:回顾性分析收集四川省某三甲医院2018年1月—2019年8月产前检查孕妇2864例临床资料,记录年龄、生育史、家族史、疾病史、文化程度、甲状腺激素水平等及甲减情况,比较不同临床特征孕妇甲减发生率,分析影响妊娠期甲减的相关因素。结果:2864例孕妇中发生甲减248例,患病率为8.7%,其中临床甲减38例,亚临床甲减210例;孕妇年龄≥35岁、产次>3次、有自然流产史、甲减家族史、合并妊娠期高血压、合并糖尿病、文化程度中专及以下,其妊娠期甲减发生率提高(P<0.05),经非条件多因素logistic回归模型分析,上述因素均为导致妊娠妇女发生妊娠期甲减的独立危险因素(P<0.05)。结论:妊娠期孕妇甲减以亚临床甲减较多见,临床针对有危险因素孕妇更应注意甲减的发生,并予以及时干预以降低甲减风险带来的不良妊娠。
Objective:To investigate the incidence of hypothyroidism of pregnant women,and to analyze the relevant factors affecting the occurrence of hypothyroidism.Methods:The clinical data of 2864 pregnant women treated in a top three hospital in Sichuan province from January 2018 to August 2019 were retrospectively analyzed.Age,childbearing history,family history,disease history,education level,thyroid hormone levels,and hypothyroidism occurrence of these women were recorded.The incidence of hypothyroidism was compared among the women with different clinical characteristics,and related factors affecting hypothyroidism during pregnancy were analyzed.Results:In these 2864 pregnant women,there were 248(8.7%)cases with hypothyroidism,which included 38 cases with clinical hypothyroidism and 210 cases with subclinical hypothyroidism.The incidence of hypothyroidism of pregnant women with over 35 years old,parity>3 times,history of spontaneous abortion,family history of hypothyroidism,hypertension during pregnancy,and diabetes,or junior college and below of education level had increased significantly(P<0.05).Unconditional multi-factor logistic regression model analysis showed that age over 35 years old,parity>3 times,history of spontaneous abortion,family history of hypothyroidism,hypertension during pregnancy,and diabetes,and junior college and below of education level of the women were independent risk factors of hypothyroidism during pregnancy(P<0.05).Conclusion:Subclinical hypothyroidism is more common type of hypothyroidism during pregnancy,so the risk factors of hypothyroidism of pregnant women should be paid more attention to in clinical practice,and intervention measures should be given to these women for reducing their adverse pregnancy outcomes.
作者
樊祯翠
徐志红
FAN Yicui;XU Zhihong(Deyang People's Hospital, Sichuan Province, 618000)
出处
《中国计划生育学杂志》
2021年第2期388-391,共4页
Chinese Journal of Family Planning
基金
四川省普及应用项目(17PJ180)。
