摘要
目的:本研究旨在探讨加减地黄饮子对帕金森病疼痛的临床研究。方法:以68例帕金森病疼痛患者为研究对象,按随机数字表法分为对照组34例,给予抗帕金森西药治疗,治疗组34例,在对照组治疗的基础上给予加减地黄饮子治疗。对比治疗前后两组中医证候积分、疼痛视觉模拟量表(VAS)评分、国王帕金森病疼痛评价量表(KPPS)评分及血清单胺类神经递质5-羟色胺(5-HT),去甲肾上腺素(NE)及神经肽Y(NPY)的变化情况,观察两组临床疗效。结果:治疗后,两组头摇肢颤、行动缓慢、腰膝酸软、善忘或神呆严重、手足出汗、头晕耳鸣、语言障碍、失眠多梦、盗汗颧红、口咽干燥、急躁时颤振加重评分均较治疗前降低,与对照组比较,治疗组头摇肢颤、行动缓慢、腰膝酸软、善忘或神呆严重、手足出汗、头晕耳鸣、语言障碍、失眠多梦、盗汗颧红、口咽干燥、急躁时颤振加重评分均更低,差异有统计学意义(P<0.05)。治疗后,治疗组临床疗效高于对照组,差异有统计学意义(P<0.05)。治疗后,两组VAS评分均较治疗前降低,与对照组比较,治疗组VAS评分更低,差异有统计学意义(P<0.05)。两组口面部疼痛、慢性疼痛、神经根性疼痛、胀痛、骨骼肌疼痛、症状波动相关疼痛、夜间疼痛评分均较治疗前降低,与对照组比较,治疗组口面部疼痛、慢性疼痛、神经根性疼痛、胀痛、骨骼肌疼痛、症状波动相关疼痛、夜间疼痛评分均更低,差异有统计学意义(P<0.05)。两组血清5-HT、NE、NPY均较治疗前上升,与对照组比较,治疗组血清5-HT、NE、NPY均更高(P<0.05)。结论:加减地黄饮子对帕金森病疼痛患者效果显著,既能降低疼痛评分,也可改善患者临床症状。
Objective:This study aims to explore the clinical study of the modified Dihuang Yinzi on Parkinson’s disease pain.Methods:A total of 68 patients with Parkinson’s disease were selected as the research objects.They were divided into a control group(34 cases with anti-Parkinson drugs)and treatment according to a random number table.Treatment group(34 cases),on the basis of the treatment of the control group,given the modified Dihuang Yinzi treatment.The scores of TCM syndromes,visual analogue scale for pain(VAS)scores,King Parkinson’s disease pain assessment scale(KPPS)scores and the serum monoamine neurotransmitter serotonin(5-HT)were compared before and after treatment.The changes of norepinephrine(NE)and neuropeptide Y(NPY)were observed in the clinical efficacy of the two groups.Results:After treatment,the two groups had head shaking,slow movement,sore waist and knees,forgetfulness or severe mental dazedness,sweating of hands and feet,dizziness,tinnitus,language disorder,and insomnia.Dreams,night sweats,zygomatic redness,dry oropharyngeal,and irritable flutter aggravated scores were all lower than before treatment.Compared with the control group,the treatment group had head shaking and limb tremor,slow movement,weak waist and knees,forgetfulness or severe daze,and extremities.Sweat,dizziness,tinnitus,language disorder,insomnia and dreaminess,night sweats,zygomatic redness,oropharyngeal dryness,and aggravated flutter during irritability were all lower,with significant differences(P<0.05).After treatment,the clinical efficacy of the treatment group was higher than that of the control group(94.12%vs 73.53%),the difference was significant(P<0.05).After treatment,the VAS scores of the two groups were lower than before treatment.Compared with the control group,the VAS scores of the treatment group were lower and the difference was significant(P<0.05).The two groups of oral and facial pain,chronic pain,radicular pain,distending pain,skeletal muscle pain,symptom fluctuation-related pain,and night pain scores were all lower than before treatment.Compared with the control group,the treatment group had oral and facial pain,chronic pain,radicular pain,distending pain,Skeletal muscle pain,symptom fluctuation-related pain,and night pain scores were all lower,with significant differences(P<0.05).The serum 5-HT,NE,and NPY of the two groups increased compared with before treatment.Compared with the control group,the treatment group serum 5-HT,NE,and NPY were all higher,and the difference was significant(P<0.05).Conclusion:Modified Dihuang Yinzi has a significant effect on patients with Parkinson’s disease pain,which can reduce pain scores and improve clinical symptoms,and is worthy of clinical application.
作者
张秀琳
惠振
王苏雷
肖婧
陈清
梁艳
唐莉莉
徐成成
陈畅
赵杨
张臻年
ZHANG Xiulin;HUI Zhen;WANG Sulei;XIAO Jing;CHEN Qing;LIANG Yan;TANG Lili;XU Chengcheng;CHEN Chang;ZHAO Yang;ZHANG Zhennian(Nanjing University of Chinese Medicine,Nanjing 210023,China)
出处
《陕西中医》
CAS
2021年第5期620-624,共5页
Shaanxi Journal of Traditional Chinese Medicine
基金
南京市卫生科技发展专项资金资助项目(YKK18134)
南京市“十三五”名中医(刘孔江)工作室建设项目(LKJ-2017-NJ)
南京中医药大学“江苏高校护理学优势学科建设工程资助项目”(2019YSHL098)
江苏中医药局“中医脑病学”重点学科培育项目(NBPY201704)
南京市“十三五”名中医(王敬卿)工作室建设项目(WJQ-2019-NJ)。
