摘要
目的了解安宁市婴幼儿及儿童血清脂溶性维生素水平,为安宁市儿童合理补充脂溶性维生素提供参考。方法于2019年6月至2020年7月,选取昆钢医院儿童体检中心925名婴幼儿及儿童,使用高效液相色谱-串联质谱法(HPLC-MS/MS)定量检测血清中脂溶性维生素;根据不同年龄、性别和季节进行脂溶性维生素营养水平分析。结果925例婴幼儿及儿童血清维生素A、25-羟基维生素D3、维生素E和维生素K的平均水平及不足和缺乏率分别为:(284±3.84)ng/mL,61.08%(565/925);(34.27±0.46)ng/mL,1.73%(16/925);(8.47±0.16)μg/mL,12.11%(112/925);(0.46±0.03)ng/mL,19.68%(182/925)。不同年龄段(3岁以下,4~6岁,7~12岁)之间及不同季节之间脂溶性维生素水平,差异有统计学意义(P<0.01)。结论安宁市婴幼儿及儿童维生素A严重缺乏,需要密切关注,合理补充。由于天然的日照优势,维生素D营养水平较好,因避免盲目过度补充。
Objective To investigate the serum fat-soluble vitamins levels in infants and children in Anning City,to provide reference data for reasonable fat-soluble vitamin supplementation.Methods From June 2019 to July 2020,925 infants and children from Children’s Physical Examination Center of Kungang Hospital were selected.High performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)was used to test the serum fat-soluble vitamins quantitatively.Then the fat-soluble vitamins levels were analyzed based on different ages,genders,and seasons.Results The average levels as well as insufficiency and deficient rates of serum vitamin A,25-hydroxyvitamin D3,vitamin E and vitamin K in 925 infants and children were(284±3.84)ng/mL,61.08%(565/925);(34.27±0.46)ng/mL,1.73%(16/925);(8.47±0.16)μg/mL,12.11%(112/925)and(0.46±0.03)ng/mL,19.68%(182/925),respectively.There were differences between different age groups(age range 0-3,4-6,7-12)and seasons(P<0.01).Conclusion There was a serious deficiency of vitamin A,which requires close attention and reasonable supplement.Due to the natural sunshine advantage in Yunnan,vitamin D nutrition level is relatively good,and excessive supplementation should be avoided.
作者
高燕
仝向磊
唐浩然
武丽
GAO Yan;TONG Xiang-lei;TANG Hao-ran;WU Li(Dept.of Pediatrics,Yunnan Kungang Hospital,Anning Yunnan 650302,China)
出处
《昆明医科大学学报》
CAS
2021年第4期44-48,共5页
Journal of Kunming Medical University
基金
昆明市卫生健康委员会科研基金资助项目(20190517114823001)。
