摘要
目的探究定量降低主食血糖负荷(GL)疗法对妊娠期糖尿病(GDM)并发高脂血症患者的影响。方法选取2019年2月至2020年7月于本院接受饮食指导的GDM合并高脂血症患者424例作为研究对象。根据自愿原则分为研究组(n=245)及对照组(n=179),对照组采取常规GDM饮食指导,研究组在对照组基础上给予定量降低主食血糖负荷疗法,比较两组干预前后空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)指标变化;对两组干预期间体重变化及新生儿出生体重进行比较;对2组不良妊娠结局进行比较。结果研究组干预8周后FPG、2hPG、HbAlc、TG、TC、LDL-C水平明显低于对照组,差异有统计学意义(P<0.05)。研究组干预8周后FINS、HOMA-IR水平明显低于对照组,ISI水平明显高于对照组,差异均有统计学意义(P<0.05)。研究组干预后体重增速及新生儿出生体重明显低于对照组,差异有统计学意义(P<0.05)。研究组不良妊娠结局总发生率为18.78%,明显低于对照组的27.93%,差异有统计学意义(P<0.05)。结论定量降低主食血糖负荷疗法对GDM并发高脂血症患者干预可明显改善患者血糖及血脂水平,降低不良妊娠结局发生率,具有良好的临床应用价值。
Objective To explore the effects of quantitatively reducing staple food glycemic load(GL)on patients with gestational diabetes mellitus(GDM)complicated by hyperlipidemia.Methods A total of 424 patients with GDM and hyperlipidemia given diet guidance in the hospital from February 2019 to July2020 were enrolled as the research objects.According to voluntary principle,they were divided into the study group(n=245)and the control group(n=179).The control group was given routine GDM diet guidance,while the study group was given the therapy of quantitatively reducing staple food GL on basis of the control group.The changes in fasting blood glucose(FPG),2 h postprandial blood glucose(2 hPG),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),fasting insulin(FINS),insulin resistance index(HOMA-IR)and insulin sensitivity index(ISI)before and after intervention,changes of weight during intervention,birth weight of neonates,and adverse pregnancy outcomes were compared between the two groups.Results After 8 weeks of intervention,the levels of FPG,2 h PG,Hb Alc,TG,TC and LDL-C in the study group were significantly lower than those in the control group(P<0.05).The levels of FINS and HOMA-IR were significantly lower than those in the control group,and the ISI level was significantly higher than that in the control group(P<0.05).After intervention,weight gain and birth weight of neonates in the study group were significantly lower than those in the control group(P<0.05),and total incidence of adverse pregnancy outcomes was significantly lower than that in the control group(18.78%vs 27.93%)(P<0.05).Conclusion The therapy of quantitatively reducing staple food GL can significantly improve the levels of blood glucose and blood lipid in patients with GDM complicated by hyperlipidemia,and reduce the incidence of adverse pregnancy outcomes.
作者
韩晔
张前
任阳
李丹
王亚娟
蒋漫红
刘丽花
HAN Ye;ZHANG Qian;REN Yang;LI Dan;WANG Yajuan;JIANG Manhong;LIU Lihua(Department of Nutrition,Hebei Petro China Central Hospital,Langfang,Hebei,China,065000;Department of Occupational Hygiene,Langfang Center for Disease Control and Prevention,Langfang,Hebei,China,065000;Department of Traditional Chinese Medicine,Hebei PetroChina Central Hospital,Langfang,Hebei,China,065000;Department of Obstetrics and Gynecology,Hebei Petro China Central Hospital,Langfang,Hebei,China,065000;Hebei Petro China Central Hospital Health Center,Langfang,Hebei,China,065000)
出处
《分子诊断与治疗杂志》
2021年第4期655-658,666,共5页
Journal of Molecular Diagnostics and Therapy
基金
河北省廊坊市科技支撑计划项目(2018013161)。
关键词
妊娠期糖尿病
高脂血症
血糖负荷
代谢指标
Gestational diabetes mellitus
Hyperlipidemia
Glycemic load
Metabolic index
