摘要
目的:应用数据挖掘技术对国家专利数据库中治疗胃食管反流病的中药配伍规律进行研究,为临床治疗、中药新药研发提供依据。方法:计算机检索中华人民共和国国家知识产权局网站建库至2020年8月1日治疗胃食管反流病的中药复方专利数据。采用中医传承辅助平台(V2.5)进行证候统计、四气五味归经统计、频次统计、关联规则、复杂网络、复杂系统熵聚类、无监督的熵层次聚类等分析。结果:最常见的主治证候为肝胃郁热证(45.16%),其次为肝胃不和证(37.63%);高频药物四气为温、寒;高频药物五味为苦、辛、甘;高频药物归经为胃、脾、肝、肺;高频单味药物有甘草(45.16%)、黄连(31.18%)、吴茱萸(26.88%)等;高频对药有"黄连-吴茱萸"(18.28%);高频角药有"黄连-柴胡-吴茱萸"(9.68%);通过关联规则发现的常用药物组合"黄连-柴胡→吴茱萸"(置信度0.90);通过复杂网络发现核心药物有吴茱萸、黄连、柴胡、甘草等;新处方有"白术、代赭石、茯苓、山药""枳壳、吴茱萸、柴胡、茯苓、炙甘草"等。结论:对于胃食管反流病的临床治疗与新药开发过程中,可选择苦、辛、甘味药物,着眼于五行生克制化,通过调整脾、胃、肝、肺之气机,达到治疗效果,代表组方有左金丸。
Objective:To study the compatibility rules of Traditional Chinese Medicines in the national patent database for the treatment of gastroesophageal reflux disease applying data mining technology,so as to provide a basis for clinical treatment and research and development of new Chinese medicines.Methods:From the establishment to August 1,2020,all compound TCM patents related to the treatment of gastroesophageal reflux disease were extracted from the national patent database searching by computer.The TCM inheritance auxiliary system(V2.5)is used to analyze syndrome statistics,four-qi,five-flavor,return to meridian statistics,frequency statistics,association rules,complex networks,complex system entropy clustering,and unsupervised entropy hierarchical clustering.Results:The most common main symptoms were stagnant heat of the liver and stomach(45.16%),followed by the discordance of the liver and stomach(37.63%);the four-Qi of high frequency drugs were warm and cold;the five-flavors of high frequency drugs were bitter,pungent,and sweet.High-frequency drugs belong to the stomach,spleen,liver,and lungs;high-frequency single drugs include licorice(45.16%),coptis(31.18%),evodia(26.88%),et al;high-frequency two herbs combination include"coptis-evodia"(18.28%);high-frequency three herbs combination include"coptis-bupleurum-evodia"(9.68%);the commonly used drug combination"coptis-bupleurum→evodia"discovered through association rules(confidence level 0.90);the core drugs found through complex networks include evodia,coptis,bupleurum,licorice,et al.The new prescriptions include"Atractylodes,ochre,poria,yam","Citrus urantium,evodia,bupleurum,poria,licorice"and so on.Conclusion:For the clinical treatment of gastroesophageal reflux disease and the development of new drugs,bitter,pungent,and sweet drugs can be selected,focusing on the restraint of the five elements,and adjusting the Qi mechanism of the spleen,stomach,liver,and lungs to achieve the therapeutic effect.The representative team was Zuo-jin pill.
作者
任梓林
陶琳
REN Zilin;TAO Lin(Department of Spleen and Stomach,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing,100010,China)
出处
《中国中西医结合消化杂志》
CAS
2021年第4期240-245,共6页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
首都卫生科研发展专项(No:首发2018-2-2231)。
关键词
胃食管反流
数据挖掘
专利
配伍规律
中药复方
gastroesophageal reflux
data mining
patent
compatibility law
Traditional Chinese Medicine compound
