摘要
目的分析当飞利肝宁联合恩替卡韦改善慢性乙肝患者肝功能的临床效果。方法选取本院消化内科2017年1月至2019年12月收治的126例慢性乙肝患者,按随机数字表法分为对照组(n=63)和观察组(n=63),对照组采用恩替卡韦治疗,观察组采用当飞利肝宁联合恩替卡韦治疗。比较两组患者治疗前后肝功能变化及治疗效果。结果治疗3、6个月后,观察组HBV-DNA转阴率分别为65.08%、88.89%,均高于对照组的41.27%、71.43%,差异有统计学意义(P<0.05)。治疗后,观察组ALT、AST、TBiL值均低于对照组,HA、LN、PC-Ⅲ值均低于对照组(P<0.05)。结论当飞利肝宁联合恩替卡韦治疗慢性乙肝有显著效果,肝功能改善明显,值得临床推广应用。
Objective To analyze the clinical effect of Dangfeiliganning combined with entecavir in improving liver function in patients with chronic hepatitis B.Methods 126 patients with chronic hepatitis B admitted to the Department of Gastroenterology in our hospital were selected.According to random number table method,they were divided into control group(n=63)and observation group(n=63).The control group was treated with entecavir,and the observation group was treated with Danafiliganin combined with entecavir.The liver function changes before and after treatment and the therapeutic effect between the two groups were compared.Results The conversion rates of HBV-DNA negative in the observation group at 3 and 6 months after treatment were 65.08%and 88.89%,respectively,which were higher than those of the control group(41.27%,71.43%),the difference was statistically significant(P<0.05).The ALT,AST and TBiL values of the observation group after treatment were lower than those of the control group,and the values of HA,LN and PC-Ⅲwere lower than the control group(P<0.05).Conclusion Dangfeiliganning combined with entecavir has significant effect on the treatment of chronic hepatitis B,liver function improvement is obvious,and it is worthy of popularization and application.
作者
王建丰
WANG Jianfeng(Department of Gastroenterology,Shanghai Renji Hospital Baoshan Branch,Shanghai,200436,China)
出处
《当代医学》
2021年第14期42-44,共3页
Contemporary Medicine
关键词
当飞利肝宁
恩替卡韦
慢性乙肝
肝功能
Dangfeiliganning
Entecavir
Chronic hepatitis B
Liver function
