摘要
复发性阿弗他溃疡(RAU)是发生于非角化黏膜最常见的口腔黏膜疾病之一,反复发作,疼痛剧烈,好发于唇、颊黏膜和舌,临床上分为轻型、重型和疱疹样3种类型。既往研究表明,RAU是一种多因素、T细胞介导的免疫失调疾病。CD4^(+)T细胞亚群与RAU的发病、发展密切相关,其分泌的细胞因子类型及功能均不同,本文就Th细胞相关细胞因子在RAU中的研究进展作一综述。
Recurrent aphthous ulcer(RAU)is one of the most common oral mucosal diseases characterized by recurrent and painful ulcerations on the movable or nonkeratinized oral mucosae.Clinically,three types of RAU,namely minor,major,and herpetiform types,can be identified.RAU more commonly affects labial mucosa,buccal mucosa,and tongue.Previous studies indicate that RAU is a multifactorial T cell-mediated immune-dysregulated disease.CD4^(+)T cell subsets are closely related to the pathogenesis and development of RAU,which secrete different cytokines and have different functions.In this paper,the research progress of Th cell related cytokines in RAU is reviewed.
作者
高小兰
王汉明
GAO Xiaolan;WANG Hanming(Department of Stomatology, Maternal and Child Health Hospital of Hubei Province, Wuhan 430000, China)
出处
《口腔医学研究》
CAS
CSCD
北大核心
2021年第5期397-400,共4页
Journal of Oral Science Research
基金
湖北省卫计委2018-2019中医药科研重点项目(编号:ZY2019Z002)。
