摘要
目的:了解新型冠状病毒肺炎(COVID-19)疫苗相关不良事件的发生情况和特点,为预防接种和科学研究提供参考。方法:调取2020年1月1日-2021年2月26日期间美国疫苗不良事件报告系统中COVID-19疫苗相关报告,对受种者一般情况、接种剂次、发生时间、临床症状等信息进行回顾性分析。结果:18184例COVID-19疫苗相关不良事件报告中,严重报告3521例(19.36%);男女比例为1∶3.26;14194例(78.06%)发生于第1剂次接种后;13675例(75.20%)发生于接种后2天之内;共涉及3092种(89694例次)临床症状,主要表现为头痛、疲劳、发热等。916例死亡报告中有767例(83.73%)为65岁及以上受种者,631例(68.89%)发生于第1剂次接种后。结论:预防接种应重点关注老年受种者;持续开展疫苗安全性监测,有助于减少疫苗犹豫、提高接种率,最终有效控制COVID-19疫情。
Objective:To investigate the occurrence and characteristics of COVID-19 vaccine-related adverse event reports in order to provide references for vaccination and scientific research.Methods:The COVID-19 vaccine-related reports from January 1st,2020 to February 26th,2021 were collected from the American Vaccine Adverse Event Reporting System(VAERS).And the general information,dose series,occurrence time,clinical symptoms and other information of COVID-19 vaccine-related adverse event reports were retrospectively analyzed.Results:There were 3521(19.36%)serious reports among 18184 cases of COVID-19 vaccine-related adverse event reports.The ratio of male to female was 1∶3.26.14194 cases(78.06%)occurred after the first inoculation;13675 cases(75.20%)occurred within 2 days after vaccination.A total of 3092 kinds of clinical symptoms(89694 cases)were involved,in which the main symptoms were headache,fatigue,fever,etc.Of the 916 death reports,767 cases(83.73%)were recipients over 65 years old and 631 cases(68.89%)occurred after the first inoculation.Conclusion:The elderly recipients should be concerned particularly when getting vaccination of COVID-19.Continuous safety monitoring of COVID-19 vaccine is helpful to reduce vaccine hesitation,improve vaccination rate,and finally effectively control the epidemic of COVID-19.
作者
张博
郭代红
郭海丽
李伯妍
王嘉熙
刘思源
于承暄
朱雨
孔祥豪
ZHANG Bo;GUO Dai-hong;GUO Hai-li;LI Bo-yan;WANG Jia-xi;LIU Si-yuan;YU Cheng-xuan;ZHU Yu;KONG Xiang-hao(Medical School of Chinese PLA,Beijing 100853,China;Department of Pharmacy,Medical Supplies Center of Chinese PLA General Hospital,Beijing 100853,China;College of Pharmacy,Chongqing Medical University,Chongqing 400016,China)
出处
《中国药物应用与监测》
CAS
2021年第2期114-117,共4页
Chinese Journal of Drug Application and Monitoring
基金
2017年军事医学创新工程重点项目(17CXZ010)
中国研究型医院学会临床重点药品的使用监测和评价研究专项(Y2021FH-YWPJ01)。
