摘要
目的:观察探究丹栀逍遥散加减治疗Graves病肝火旺盛证患者的临床疗效。方法:选取64例Graves病肝火旺盛证患者作为研究对象,采取随机抽样法进行分组,分别为采用甲巯咪唑片治疗的对照组和采用丹栀逍遥散加减联合甲巯咪唑片治疗的治疗组,每组各32例。对2组的临床疗效进行分析比较。结果:治疗前2组患者症状评分比较,差异无统计学意义;治疗后2组患者症状评分明显低于治疗前,且治疗组症状评分均低于对照组,差异有统计学意义。治疗前2组患者的实验室指标血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)相比较,差异无统计学意义;经过治疗,相较于对照组,治疗组FT3、FT4显著下降,差异具有统计学意义。不良反应发生率对照组高于治疗组,差异具有统计学意义。治疗组有效率为90.6%,对照组有效率68.8%,治疗组明显优于对照组,差异具有统计学意义。结论:丹栀逍遥散加减治疗Graves病肝火旺盛证患者的临床疗效显著,且明显优于单独使用甲巯咪唑片,值得临床推广应用。
Objective:To observe and explore the clinical efficacy of Danzhi Xiaoyao powder in the treatment of patients with Graves’disease with exuberant liver-fire syndrome.Methods:Sixty-four patients with Graves’disease with exuberant liver-fire syndrome were selected as the research objects,and random sampling was adopted to group them into a control group treated with methimazole tablets and a treatment group treated with Danzhi Xiaoyao powder plus or minus combined with methimazole tablets,32 cases in each group.The clinical efficacy of the two groups was analyzed and compared.Results:The symptom scores of the two groups of patients were compared before treatment,and the difference was not statistically significant.After treatment,the symptom scores of the two groups were significantly lower than those before treatment,and the symptom scores of the treatment group were lower than those of the control group,and the difference was statistically significant.Before treatment,the laboratory indexes of the two groups of patients were compared with serum free triiodothyronine(FT3)and serum free thyroxine(FT4),and the difference was not statistically significant;after treatment,compared with the control group,the treatment group FT3 FT4 decreased significantly,and the difference was statistically significant.The incidence of adverse reactions in the control group was higher than that in the treatment group,and the difference was statistically significant.The effective rate of the treatment group was 90.6%,and the effective rate of the control group was 68.8%.The treatment group was significantly better than the control group,and the difference was statistically significant.Conclusion:Danzhi Xiaoyao powder has a significant clinical effect in the treatment of patients with Graves’disease with exuberant liver-fire syndrome,and is significantly better than the use of methimazole tablets alone.It is worthy of clinical application.
作者
高蕊
胡剑卓
GAO Rui;HU Jianzhuo(Hunan University of Chinese Medicine,Hunan Changsha 410208,China;The Second Affiliated Hospital of Hunan University of Chinese Medicine,Hunan Changsha 410005,China)
出处
《中医药临床杂志》
2021年第4期730-733,共4页
Clinical Journal of Traditional Chinese Medicine
基金
湖南省自然科学基金资助项目(NO.2018JJ6037)。
关键词
丹栀逍遥散
GRAVES病
肝火旺盛证
Danzhi Xiaoyao powder
Graves disease
Syndrome of exuberant irascibility
