摘要
目的探讨局部晚期直肠癌患者新辅助治疗前外周血炎症指标、血红蛋白与新辅助治疗疗效的相关性。方法收集48例行新辅助治疗前直肠癌患者的临床资料,应用SPSS22.0软件进行数据统计分析。结果入组的48例直肠癌患者中,达到病理完全缓解(pCR)9例(18.9%)。单因素分析显示,年龄和血红蛋白水平与新辅助治疗疗效显著相关(P<0.05)。多因素分析显示,血红蛋白水平是局部晚期直肠癌新辅助治疗疗效的影响因素(P=0.020),而年龄与新辅助治疗疗效无明显相关性(P=0.718)。结论本研究结果表明血红蛋白水平与新辅助治疗疗效显著相关,而新辅助治疗前外周血中性粒细胞计数、淋巴细胞计数、血小板计数、嗜酸性粒细胞计数、嗜碱性粒细胞计数、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)等炎症指标与新辅助治疗疗效无相关性。
Objective To investigate the correlation between peripheral blood inflammatory indexes, hemoglobin and the efficacy of neoadjuvant therapy in patients with locally advanced rectal cancer before neoadjuvant therapy.Methods The clinical data of 48 patients with rectal cancer before neoadjuvant therapywere collected and analyzed by SPSS22.0 software.Results Among the 48 patients with rectal cancer, 9 patients(18.9%) achieved pathological complete remission(pCR).Univariate analysis showed that age and hemoglobin level were significantly correlated with the efficacy of neoadjuvant therapy(P<0.05).Multivariate analysis showed that hemoglobin level was a factor affecting the efficacy of neoadjuvant therapy for locally advanced rectal cancer(P=0.020),but there was no significant correlation between age and the efficacy of neoadjuvant therapy(P=0.718).Conclusions The results of this study showed that the level of hemoglobin is significantly correlated with the efficacy of neoadjuvant therapy, but before neoadjuvant therapy, peripheral blood neutrophil count, lymphocyte count, platelet count, eosinophil count, basophil count, neutrophil/lymphocyte ratio(NLR),platelet/lymphocyteratio(PLR) and other inflammatory indicators are not related to the efficacy of neoadjuvant therapy.
作者
张雅婷
张维
孔德琛
张正涛
马瑞忠
郝福荣
王明臣
ZHANG Yating;ZHANG Wei;KONG Dechen;ZHANG Zhengtao;MA Ruizhong;HAO Furong;WANG Mingchen(Department of Oncology,Weifang Medical University,Weifang 261053,China;Department of Radiation Oncology,Weifang People’s Hospital)
出处
《潍坊医学院学报》
2021年第1期5-8,共4页
Acta Academiae Medicinae Weifang
基金
山东省医药卫生科技发展计划(项目编号:2019WS249)。
