摘要
目的观察替扎尼定治疗椎间盘源性腰痛患者的临床效果。方法将77例患者依据随机数字表法分为对照组39例与试验组38例。对照组在常规治疗的基础上给予盐酸替扎尼定安慰剂,每次4 mg,每天3次,口服。试验组在常规治疗的基础上给予盐酸替扎尼定片,每次4 mg,每天3次,口服。2组均治疗28 d。比较2组的视觉模拟评分(VAS)、日本骨科协会(JOA)评分、Oswestry功能障碍指数量表(ODI)评分、白细胞介素-6(IL-6)、白细胞介素-1(IL-1)、临床疗效和药物不良反应发生情况。结果治疗后,对照组和试验组的总有效率分别为79.49%(31例/39例)和97.37%(37例/38例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的VAS分别为(2.53±0.22)和(3.31±0.31)分,JOA评分分别为(25.79±3.66)和(23.25±3.35)分,ODI评分分别为(21.55±3.53)和(25.84±3.38)分,IL-6分别为(20.15±6.62)和(33.23±5.37)pg·mL^(-1),IL-1分别为(9.51±2.98)和(15.72±3.12)pg·mL^(-1),差异均有统计学意义(均P<0.05)。试验组和对照组在治疗过程中的药物不良反应发生率分别为13.16%和10.26%,差异无统计学意义(P>0.05)。结论对于适宜采用保守治疗的椎间盘源性腰痛患者,在常规治疗方法的基础上联合使用替扎尼定,有助于提升疗效,改善疼痛以及功能的指标,降低血清炎性反应因子水平,具有良好的安全性。
Objective To observe the clinical effect of tizanidine in the treatment of patients with discogenic back pain.Methods According to the random number method,77 patients were divided into control group(n=39)and a treatment group(n=38).Control group was given tizanidine hydrochloride placebo 4 mg each time,tid,orally on the basis of control group.Ttreatment group was given tizanidine hydrochloride tablets 4 mg each time,tid,orally on the basis of control group.The treatment in both groups was 28 d.The visual analogue scale(VAS),the Japanese Orthopedic Association(JOA)score,the Oswestry dysfunction index(ODI)score,interleukin-6(IL-6),interleukin-1(IL-1),clinical effect and adverse drug reactions in two groups were observed.Results After treatment,the total effective rates in control group and treatment group were 79.49%(31 cases/39 cases)and 97.37%(37 cases/38 cases),with significant difference(P<0.05).After treatment,the VAS in treatment group and control group were(2.53±0.22)and(3.31±0.31)points,the JOA score were(25.79±3.66)and(23.25±3.35)points,the ODI score were(21.55±3.53)and(25.84±3.38)points,IL-6 were(20.15±6.62)and(33.23±5.37)pg·mL-1,IL-1 were(9.51±2.98)and(15.72±3.12)pg·mL^(-1),all with significant difference(all P<0.05).The incidence of adverse drug reactions in treatment group and control group during treatment were 13.16%and 10.26%,without significant difference(P>0.05).Conclusion For patients with discogenic low back pain who are suitable for conservative treatment,tizanidine combined with conventional treatment methods can help improve clinical effect,improve pain and functional indicators,and reduce serum inflammatory response factor levels,with good safety.
作者
章建新
郑建平
谢伟
李正富
ZHANG Jian-xin;ZHENG Jian-ping;XIE Wei;LI Zheng-fu(Department of Orthopaedics and Traumatology,Quzhou Hospital of Traditional Chinese Medicine,Quzhou 324000,Zhejiang Province,China;Department of Rheumatology,Xinhua Hospital,Hangzhou 310005,Zhejiang Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2021年第8期970-973,共4页
The Chinese Journal of Clinical Pharmacology
关键词
替扎尼定
椎间盘源性腰痛
肾上腺素受体
保守治疗
tizanidine
discogenic low back pain
adrenergic receptors
conservative treatment
