摘要
目的初步评价紫草膏治疗轻度儿童特应性皮炎(AD)的疗效和安全性,并分析其作用机制.方法儿童特应性皮炎(AD)患者200例,编号后随机分为观察组和对照组,每组各100例.观察组给予盐酸西替利嗪片口服,局部外用院内制剂紫草膏;对照组在观察组系统治疗的基础上外用丁酸氢化可的松乳膏.观察比较两组患者治疗前后的SCORAD评分、皮损区和正常皮肤的角质层含水量、经表皮水分丢失量(TEWL)、pH值等.结果治疗后两组SCORAD评分均下降,两组角质层含水量均上升,经表皮水分丢失量(TEWL)减少、pH值降低.结论紫草膏外用治疗AD疗效确切,且副作用少,安全性高.
Objective To preliminarily evaluate the efficacy and safety of Zicao Ointment in the treatment of mild atopic dermatitis(AD)in children,and analyze its mechanism of action.Methods 200 children with atopic dermatitis(AD)were randomly divided into observation group and control group after numbering,with 100 cases in each group.The observation group was given cetirizine hydrochloride tablets orally,and topical in-hospital preparation zicao ointment was used locally;the control group was given topical hydrocortisone butyrate cream based on systemic treatment in the observation group.The SCORAD score,skin lesion area and normal skin stratum corneum water content,transepidermal water loss(TEWL),pH value,etc.were observed and compared before and after treatment between the two groups.Results After treatment,the SCORAD scores of the two groups decreased,the water content of the stratum corneum in both groups increased,the amount of transepidermal water loss(TEWL)decreased,and the pH value decreased.Conclusion The external use of Zicao ointment has a definite curative effect in the treatment of AD,with few side effects and high safety.
出处
《浙江临床医学》
2021年第4期536-538,共3页
Zhejiang Clinical Medical Journal
基金
浙江省中医药科技计划(2017ZB037)。
关键词
特应性皮炎
紫草膏
皮肤屏障
Atopic dermatitis
Zicao ointment
Skin barrier
