摘要
目的:探究Q开关1064nm Nd:YAG激光联合纳晶微针治疗黄褐斑的疗效及安全性。方法:选取2017年9月-2019年9月于笔者科室就诊的86例黄褐斑患者,随机分为治疗组(n=43)和对照组(n=43)。治疗组:采用Q开关1064nm Nd:YAG激光联合纳晶微针导入氨甲环酸注射液治疗;对照组:采用Q开关1064nm Nd:YAG激光治疗,每次治疗间隔2周,4次为1个疗程,两组均治疗2个疗程。治疗结束后比较两组MASI评分、临床疗效、满意度及不良反应发生率,随访12周观察复发率。结果:治疗组MASI评分降低、有效率以及满意度均高于对照组,治疗组不良反应发生率、复发率均低于对照组,差异具有统计学意义(P<0.05)。结论:Q开关1064nm Nd:YAG激光联合纳晶微针导入氨甲环酸治疗黄褐斑较单独使用激光治疗效果好,不良反应发生率低,患者满意度高,值得临床推广应用。
Objective To investigate the effects and safety of Q-switch 1064nm Nd:YAG laser combined with nanocrystal microneedle in treatment with melasma.Methods 86 patients with melasma in our hospital from September 2017 to September 2019 were selected and randomly divided into treatment group(n=43)and control group(n=43).The control group were applied Q-switch 1064nm Nd:YAG laser,and the treatment group were applied Q-switch 1064nm Nd:YAG laser combined with nanocrystal microneedle.nanocrystals were used to assist transdermal administration of tranexamic acid injection.Each treatment interval was 2 weeks,4 times as a course of treatment,and the two groups were applied for 2 courses.The MASI scores,clinical efficacy,patient satisfaction and the incidence of adverse reactions were compared between the two groups,and follow up for 12 weeks to observed the recurrence rate after treatment.Results The decrease of MASI scores,effective rate and satisfaction in the treatment group were all higher than those in the control group,while the incidence and recurrence rates of the adverse reactions were lower than the control group.The difference was statistically significant(P<0.05).Conclusion Q-switched 1064nm Nd:YAG laser combined with nanocrystal microneedle infusion of tranexamic acid in the treatment of melasma was more effective than laser treatment only,with less adverse reactions,and the patient’s satisfaction was higher,and was worthy of clinical promotion and application.
作者
熊友华
邓映
杨洪秋
杜宇
XIONG You-hua;DENG Ying;YANG Hong-qiu;DU Yu(Medical Cosmetology Center,Affiliated Hospital of Traditional Chinese Medicine,Southwest Medical University,Luzhou 646000,Sichuan,China)
出处
《中国美容医学》
CAS
2021年第4期22-26,共5页
Chinese Journal of Aesthetic Medicine
