摘要
目的:探讨马来酸桂哌齐特联合纳洛酮对后循环缺血(PCI)患者的治疗效果。方法:采用前瞻性随机试验方法,选择2017年1月至2019年10月宜春市人民医院接诊的80例PCI患者随机编号1~80号,将单数归为对照组,双数归为观察组,各40例。对照组接受纳洛酮治疗,观察组在对照组基础上联用马来酸桂哌齐特治疗,比较两组临床疗效、血流动力学指标[心率(HR)、平均动脉压(MAP)]及药物不良反应发生率。结果:治疗结束后,与对照组相比,观察组HR、MAP较低,治疗总有效率较高(P<0.05);两组药物不良反应发生率比较差异无统计学意义(P>0.05)。结论:马来酸桂哌齐特联合纳洛酮治疗可有效提高后循环缺血患者临床治疗效果,改善其血流动力学指标,用药安全有效。
Objective:To investigate the treatment effect of cinepazide maleate combined with naloxone in patients with posterior circulation ischemia(PCI).Methods:A prospective randomized trial method was used to select 80 patients with PCI admitted and treated in Yichun People's Hospital from January 2017 to October 2019,randomly numbered them 1-80,patients with odd number were divided into the control group,patients with even number were divided into the observation group,each with 40 cases.The control group was given naloxone,and the observation group was treated with cinepazide maleate based on control group.The clinical efficacy,indexes of hemodynamics[heart rate(HR),mean arterial pressure(MAP)]and the incidence of adverse drug reactions were compared between two groups.Results:After the end of treatment,compared with the control group,the total effective rate of observation group was higher,HR,MAP were lower,there were statistical significant differences(P<0.05);There was no statistical difference in the comparison of the incidence of adverse drug reactions between two groups(P>0.05).Conclusion:Cinepazide maleate combined with naloxone in treatment of patients with posterior circulation ischemia can increase clinical curative effects and improve the indexes of hemodynamics,which is safe and effective.
作者
彭向玉
柳凤华
李晶
肖蓉
刘莉琼
漆苏
PENG Xiangyu;LIU Fenghua;LI Jing;XIAO Rong;LIU Liqiong;QI Su(Yichun People's Hospital,Yichun Jiangxi 336000,China;Yichun Second People's Hospital,Yichun Jiangxi 336000,China)
出处
《药品评价》
CAS
2021年第6期359-361,共3页
Drug Evaluation
关键词
颈动脉疾病
椎底动脉供血不足
后循环缺血
马来酸桂哌齐特
纳洛酮
血流动力学
Carotid artery diseases
Vertebrobasilar insufficiency
Posterior circulation ischemia
Cinepazide maleate
Naloxone
Hemodynamics
