摘要
目的:探讨药物涂层球囊经皮腔内血管成形术(PTA)治疗下肢动脉硬化闭塞症(LEAOD)的临床应用效果。方法:选取2018年6月-2020年4月本院收治的LEAOD患者96例,按照随机数字表法分为观察组(n=48)和对照组(n=48)。观察组给予药物涂层球囊PTA治疗,对照组给予普通球囊PTA治疗。比较两组术后30 d、3个月、6个月靶动脉段股浅动脉血管内径、踝肱指数(ABI)及靶动脉血管狭窄程度,并随访6个月时间,记录两组再狭窄率、不良事件发生率及截肢率。结果:术后30 d,观察组和对照组靶动脉段股浅动脉血管内径、ABI、靶动脉血管狭窄程度比较差异无统计学意义(P>0.05)。术后3、6个月,观察组靶动脉段股浅动脉血管内径、ABI高于对照组,靶动脉血管狭窄程度低于对照组,差异有统计学意义(P<0.05)。随访时间内,观察组再狭窄率低于对照组,差异有统计学意义(P<0.05),两组不良事件发生率和截肢率比较差异无统计学意义(P>0.05)。结论:药物涂层球囊PTA治疗LEAOD的近期效果及安全性与普通球囊PTA相近,但远期效果优于普通球囊PTA,更利于改善靶动脉段股浅动脉血管内径、踝肱指数,降低再狭窄率。
Objective:To investigate the clinical effect of drug coated balloon percutaneous transluminal angioplasty (PTA) for lower extremity atherosclerotic occlusive disease (LEAOD).Method:A total of 96 patients with LEAOD admitted to our hospital from June 2018 to April 2020 were selected and randomly divided into the observation group (n=48) and the control group (n=48).The observation group was treated with drug coated balloon PTA,the control group was treated with ordinary balloon PTA.The diameter of target artery segments superficial femoral artery vessel,ankle brachial index (ABI) and the stenosis degree of target artery were compared between the two groups 30 d,3 months and 6 months after operation.The restenosis rate,incidence of adverse events and amputation rate were recorded after 6 months follow-up.Result:There was no significant difference in diameter of target artery segments superficial femoral artery vessel,ABI and stenosis degree of target artery between the two groups 30 d after operation (P>0.05).The diameter of target artery segments superficial femoral artery vessel and ABI in the observation group were higher than those in the control group at 3 and 6 months after operation,and the stenosis degree of the target artery was lower than that of the control group,the differences were statistically significant (P<0.05).During the follow-up period,the restenosis rate in the observation group was lower than that in the control group,and the difference was statistically significant (P<0.05),and there were no significant differences in the incidence of adverse events and amputation rate between the two groups (P>0.05).Conclusion:The short-term efficacy and safety of drug coated balloon PTA in the treatment of LEAOD are similar to those of ordinary balloon PTA,but the long-term efficacy is better,which is more conducive to improve the diameter of target artery segments superficial femoral artery vessel and ABI,and reduce the restenosis rate.
作者
梁嘉杰
潘文
LIANG Jiajie;PAN Wen(Central Hospital of Chancheng District in Foshan,Foshan 528000,China;不详)
出处
《中外医学研究》
2021年第10期53-56,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
下肢动脉硬化闭塞症
药物涂层球囊
经皮腔内血管成形术
再狭窄率
踝肱指数
Lower extremity atherosclerotic occlusive disease
Drug coated balloon
Percutaneous transluminal angioplasty
Restenosis rate
Ankle brachial index
