摘要
目的:探讨甲状腺次全切除术治疗甲状腺癌的临床效果及对患者血清白介素17(IL-17)、可溶性白介素-2R(SIL-2R)表达水平的影响。方法:选取本院2017年1月-2019年1月收治的73例甲状腺癌患者,按照术式不同分为对照组36例、观察组37例。对照组采用全甲状腺切除术治疗,观察组采用甲状腺次全切除术治疗。比较两组手术时间、切口长度、出血量、术后镇痛时间、术后住院时间和血清IL-17、SIL-2R表达水平、并发症发生情况。结果:观察组手术时间、切口长度、出血量、术后镇痛时间、术后住院时间均优于对照组(P<0.05)。术后24 h,两组血清IL-17、SIL-2R表达水平均高于术前,但观察组上述指标均低于对照组(P<0.05);术后30 d,两组血清IL-17、SIL-2R表达水平均较术前降低(P<0.05),但术后30 d,两组上述指标比较,差异均无统计学意义(P>0.05)。观察组呼吸困难、声音嘶哑、喉返神经损伤、低钙血症发生率均低于对照组(P<0.05)。结论:甲状腺次全切除术治疗甲状腺癌具有手术时间短、切口小、出血少、术后镇痛时间短、术后住院时间短、创伤应激小、并发症少的优势,值得推广。
Objective:To investigate the clinical effect of subtotal thyroidectomy for thyroid cancer and its effect on the expression levels of serum interleukin-17(IL-17)and soluble interleukin-2R(SIL-2R)in patients.Method:A total of 73 patients with thyroid cancer treated in our hospital from January 2017 to January 2019 were selected,they were divided into control group(36 cases)and observation group(37 cases)according to different surgical methods.The control group was treated with total thyroidectomy,while the observation group was treated with subtotal thyroidectomy.The operation time,incision length,blood loss,postoperative analgesia time,postoperative hospital stay,serum IL-17,SIL-2R levels and complications were compared between the two groups.Result:The operation time,incision length,blood loss,postoperative analgesia time and postoperative hospital stay in the observation group were better than those in the control group(P<0.05).At 24 h after operation,the expression levels of serum IL-17 and SIL-2R in both groups were higher than those before operation,but the above indexes in observation group were lower than those in control group(P<0.05).30 d after operation,the expression levels of serum IL-17 and SIL-2R in the two groups were lower than those before operation(P<0.05),however,30 d after surgery,there were no significant differences in the above indicators between the two groups(P>0.05).The incidence of dyspnea,hoarseness,recurrent laryngeal nerve injury,hypocalcemia in the observation group were lower than those in the control group(P<0.05).Conclusion:Subtotal thyroidectomy for thyroid cancer has the advantages of shorter operation time,smaller incision,less bleeding,shorter postoperative analgesia time,shorter postoperative hospital stay,less traumatic stress and fewer complications,which is worthy of popularization.
作者
高树林
GAO Shulin(Jiamusi Anorectal Hospital,Jiamusi 154002,China)
出处
《中国医学创新》
CAS
2021年第11期28-31,共4页
Medical Innovation of China
