摘要
目的比较高孕激素状态下促排卵(PPOS)方案与其他3种不同促排卵方案的实验室和临床妊娠结局。方法回顾性分析2019年6月~2020年1月在我院生殖中心行体外受精/卵泡浆内单精子显微注射(IVF/ICSI)共430个取卵周期和256个冻融周期,观察实验室相关数据、受精情况及妊娠结局的差异。结果取卵周期中,PPOS方案82个,长方案152个,短方案116个,拮抗剂方案80个。PPOS组获卵数(11.1±7.3)、受精率(85.6%)、卵裂率(95.1%)、可用胚胎数(4.5±3.1)、优质胚胎率(20.2%)等与其他3组之间差异均无统计学意义(P>0.05)。冻融周期中,PPOS方案27个周期,拮抗剂方案107个,长方案78个,短方案44个。PPOS组种植率(26.2%)、临床妊娠率(63.0%)和流产率(11.8%)与其他各组比较差异无显著性(P>0.05),但临床妊娠率和种植率高于其他各组(P>0.05)。结论PPOS方案和其他3种促排卵相比,对卵泡发育、卵母细胞和胚胎质量没有影响,而且临床妊娠率和种植率有升高的趋势,可以作为常规促排卵方案的一种新的选择。
Objective To analyze the clinical outcomes of progestin primed ovarian stimulation(PPOS)compared with the other three different controlled ovarian hyperstimulation(COH)protocols in fresh embryo transfer(ET)and frozen-thawed embryo transfer(FET)cycles.Methods A total of 430 oocyte pick-up cycles and 272 FET cycles were retrospectively analyzed.Number of oocytes retrieved,laboratory indexes and pregnancy outcome of FET were compared.Results The mean oocytes retrieved(11.1±7.3),fertilization rate(85.6%),cleavage rate(95.1%)and excellent embryo rate(20.2%)as well as transplantable embryo rate(4.5±3.1)of the PPOS group did not show significant differences compared with the other 3 subgroups(all P<0.05)in fresh cycle.As for pregnancy outcomes in FET cycles,no statistically significant differences were observed among the four groups in embryo implantation rate(26.2%),clinical pregnancy rate(63.0%)and abortion rate(11.8%)(all P<0.05).However,embryo implantation rate,clinical pregnancy rate was higher in PPOS group compared with the other groups.Conclusion Compared with the other three ovulation stimulation programme,PPOS might be used as a new alternative for controlled ovulation stimulation protocols.
作者
李建华
焦婷婷
王建业
李常山
董攀
陈曦
张水文
LI Jian-hua;JIAO Ting-ting;WANG Jian-ye;LI Chang-shan;DONG Pan;CHEN Xi;ZHANG Shui-wen(Center ofReproductive Medicine and Genetics,the Seventh Medical Center of Chinese People’s Liberation Army General Hospital,Beijing 100700,China;Center forReproductive Medicine,Peking University Second Hospital,Beijing 100044,China)
出处
《解剖学报》
CAS
CSCD
北大核心
2021年第2期284-288,共5页
Acta Anatomica Sinica
基金
国家自然科学基金(81401271)。
关键词
控制性超促排卵
高孕激素状态下促排卵方案
冻融胚胎移植
临床妊娠率
体外受精
卵泡浆内单精子显微注射
女性
Controlled ovarian hyperstimulation
Progestin primed ovarian stimulation
Frozen-thawed embryo transfer
Clinical pregnancy rate
In vitro fertilization
Intracytoplasmic sperm injection
Female
