摘要
目的分析山东三甲中医院治疗局灶性子宫腺肌病(AM)的中医用药规律。方法从医院信息系统收集局灶性AM患者资料,应用复杂网络、关联规则数据挖掘等分析方法,总结中医药治疗局灶性AM的用药规律。结果根据纳入、排除标准共收集处方761首,涉及中药260味。使用频次高的中药有醋香附、蒲黄、醋延胡素、当归等;药物功效以补虚、活血化瘀、理气为主;药物归经频次最高的为肝经;关联分析得到核心药对组合为"醋香附-醋延胡索"和"当归-川芎";复杂网络分析得到核心处方为醋香附、醋延胡索、当归、白芍、川芎、蒲黄、益母草、党参、牡蛎,以及3层药物配伍加减组合。结论治疗局灶性AM的核心药物为醋香附、醋延胡索、当归、白芍、川芎、蒲黄、益母草、党参、牡蛎,以理气止痛、活血化瘀为基本治法,兼以补虚及软坚散结,辨证加以温里、清热、解毒等配伍。
Objective To analyze the regularity of traditional Chinese medicine in the treatment of focal adenomyosis(AM) in upper third-class traditional Chinese Medicine Hospital of Shandong Province.MethodsThe data ofpatients with focal AM was collected from the hospital information system, and the drug use rules of traditionalChinese medicine in the treatment of focal AM were summarized by using complex network,association rule datamining and other analysis methods.ResultsAccording to the inclusion and exclusion criteria, a total of 761 prescriptions and 260 traditional Chinese medicines were collected. The most frequently used traditional Chinesemedicines are vinegar Rhizoma Cyperi,Pollen Typhae,vinegar,Rhizoma Corydalis,Angelica sinensis,etc. Themain effects of the drugs are tonifying deficiency,promoting blood circulation and removing blood stasis,regulatingqi,and the highest frequency of channel tropism is the liver meridian. Correlation analysis showed that the core drugpairs were "vinegar Rhizoma Cyperi-vinegar Rhizoma Corydalis" and "Angelica sinensis-Ligusticum chuanxiong".Complex network analysis showed that the core prescriptions were composed of vinegar Rhizoma Cyperi, vinegarRhizoma Corydalis, Radix angelicae Sinensis, Radix Paeoniae Alba, Ligusticum chuanxiong, Pollen Typhae,motherwort, Codonopsis pilosula, oyster, and three-layer combination of drugs was obtained.ConclusionThecore drugs for the treatment of focal AM are vinegar Rhizoma Cyperi,vinegar Rhizoma Corydalis,Radix angelicae Sinensis,Radix Paeoniae Alba,Ligusticum chuanxiong,Pollen Typhae,Leonurus,Codonopsis pilosula,oyster.The basic treatment should be based on regulating qi and relieving pain,promoting blood circulation and removingblood stasis with tonifying deficiency and dispelling soft firmness,and dialectically combined with warming,heat-clearing and detoxification.
作者
丁楠
师伟
程文秀
于航
赵晓晓
徐丽
DING Nan;SHI Wei;CHENG Wenxiu;YU Hang;ZHAO Xiaoxiao;XU Li(Shandong University of Traditional Chinese Medicine,Jinan 250014 Shandong,China;The Affiliated Hospital of Shandong University of Chinese Medicine,Jinan 250014 Shandong,China;Shandong Provincial Hospital,Shandong University,Jinan 250021 Shandong,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2021年第3期435-440,共6页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金面上项目(81873330)
山东省科学技术厅山东省重点研发计划项目(2017G006017)
科学技术部国家重点研发计划项目(2017YFC1703502)。
关键词
局灶性子宫腺肌病
中医药
数据挖掘
复杂网络分析
用药规律
理气止痛
活血化瘀
Focal adenomyosis
traditional Chinese medicine
data mining
complex network analysis
medication rule
regulating qi and relieving pain
promoting blood circulation and removing blood stasis
