摘要
新型冠状病毒感染可导致机体内炎症因子过度表达,引发细胞因子风暴,对机体造成严重损害。糖皮质激素具有抗炎特性,可能是一种有效的治疗选择,是否将其应用于治疗新型冠状病毒肺炎(COVID-19)以及治疗剂量的选择一直备受争议。本文结合相关文献,阐述了糖皮质激素治疗COVID-19的理论依据、临床证据、争议及具体措施等内容,以期今后能更合理地使用糖皮质激素治疗COVID-19患者。
The infection of 2019-nCoV can lead to overexpression of inflammatory factors,triggering cytokine storm and causing serious damage to the body.Glucocorticoids have anti-inflammatory properties and may be an effective treatment option.The use and dosage of glucocorticoids in coronavirus disease 2019(COVID-19)remains controversial.This article reviews the theoretical basis,clinical evidence,debates and specific measures of glucocorticoids in the treatment of COVID-19,to provide reference for rational application of glucocorticoids in the future.
作者
郭婉茹
徐凯进
Guo Wanru;Xu Kaijin(State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)
出处
《中华临床感染病杂志》
CAS
CSCD
2021年第1期21-23,共3页
Chinese Journal of Clinical Infectious Diseases
基金
国家科技重大专项(2017ZX10105001)。
