摘要
目的分析重庆市主城区妊娠早期妇女乙肝病毒、丙肝病毒、人类免疫缺陷病毒(HIV)、梅毒螺旋体(TP)及TORCH[弓形虫(TOX)、风疹病毒(RV)、巨细胞病毒(CMV)、单纯疱疹病毒(HSV)]的感染情况,促进优生优育。方法收集2017-2019年在重庆市妇幼保健院产科门诊建档的妊娠早期妇女59 157例,采用化学发光法检测血清中乙肝表面抗原(HBsAg)、乙肝表面抗体、乙肝e抗原(HBeAg)、乙肝e抗体、乙肝核心抗体(抗-HBc)、丙肝病毒抗体(抗-HCV)、HIV抗原及抗体(HIV-Ag/Ab)、抗-TP及TORCH;采用甲苯胺红不加热试验检测梅毒非特异性抗体;采用荧光定量PCR检测HBsAg阳性妊娠早期妇女血清中HBV-DNA。结果 2017-2019年重庆市主城区妊娠早期妇女HBsAg总阳性率为5.89%,且呈逐年下降趋势,差异均有统计学意义(P<0.05);抗-HCV、HIV-Ag/Ab、抗-TP总阳性率分别为0.15%、0.05%、0.72%,2017-2019年阳性率差异无统计学意义(P>0.05)。妊娠早期妇女随着年龄的增长,HBsAg阳性率逐渐升高,差异有统计学意义(P<0.05)。HBV感染妊娠早期妇女以"小三阳"模式所占比例最高,为74.07%(1 197/1 616),其次为"大三阳"模式,占20.05%(324/1 616)。2017-2019年妊娠早期妇女CMV-IgG及IgM阳性检出率最高,分别为95.78%(726/758)、4.34%(33/761);TOX-IgG与IgM阳性检出率最低,分别为4.99%(71/1 422)、0.92%(13/1413)。2017-2019年TORCH阳性检出率比较,差异无统计学意义(P>0.05)。不同年龄妊娠早期妇女TORCH阳性检出率比较,差异无统计学意义(P>0.05)。结论重庆市主城区妊娠早期妇女存在优生优育相关病原体感染的现象,应加强对育龄夫妇的宣传教育,做好孕前和孕期筛查工作,推进优生优育,提高人口素质。
Objective To analyze the infection status of hepatitis B virus,hepatitis C virus,human immunodeficiency virus(HIV),treponema pallidum(TP)and TORCH[Toxoplasma gondii(TOX),rubella virus(RV),cytomegalovirus(CMV),herpes simplex virus(HSV)]in early pregnancy in Chongqing,so as to provide eugenic guidance.Methods A total of 59157 serum samples of pregnant women in the first trimester of pregnancy in obstetric outpatient department of Chongqing Health Center for Women and Children from 2017 to 2019 were collected.The serum markers of hepatitis B surface antigen(HBsAg),hepatitis B surface antibody,hepatitis B e antigen(HBeAg),hepatitis B e antibody,hepatitis B core antibody(HBc-Ab),hepatitis C virus antibody(HCV-Ab),human immunodeficiency virus antigen and antibody(HIV-Ag/Ab),TP-Ab and TORCH were detected by chemiluminescent microparticle immunoassa.The nonspecific antibody to syphilis was detected by TURST.The HBV-DNA in serum of pregnant women with HBsAg positive was detected by fluorescence quantitative PCR.Results From 2017 to 2019,the positive rate of HBsAg in early pregnant women in Chongqing main urban area was 5.89%,which was decreased year by year(P<0.05).The positive rates of HCV-Ab,HIV-Ag/Ab and TP-Ab were 0.15%,0.05%and 0.72%respectively,and there was no significant difference in the positive rates from 2017 to 2019(P>0.05).With the increase of age,the positive rate of HBsAg increased gradually in the early pregnant women,the difference was statistically significant(P<0.05).Among the pregnant women with hepatitis B infection,those with HBsAg,HBeAb and HBcAb test positive accounted for the highest proportion,accounting for 74.07%(1197/1616),followed by those with HBsAg,HBeAg and HBcAb test positive,accounting for 20.05%(324/1616).From 2017 to 2019,the positive rates of CMV IgG and IgM were the highest,95.78%(726/758)and 4.34%(33/761)respectively,and the positive rates of TOX-IgG and IgM were the lowest,4.99%(71/1422)and 0.92%(13/1413)respectively.There was no significant difference in positive rate of TORCH from 2017 to 2019 and positive rate of TORCH among women at different ages(P>0.05).Conclusion There is a phenomenon of eugenics related pathogens infection in early pregnant women in Chongqing main urban area,it is necessary to strengthen the propaganda and education for couples of childbearing age,do a good job in screening before and during pregnancy,promote eugenics and eugenics,and improve the quality of the population.
作者
殷欢
王继超
吴凤
颜若琳
谭诗
YIN Huan;WANG Jichao;WU Feng;YAN Ruolin;TAN Shi(Department of Clinical Laboratory,Chongqing Health Center for Women and Children,Chongqing 401147,China)
出处
《检验医学与临床》
CAS
2021年第10期1381-1384,1389,共5页
Laboratory Medicine and Clinic
关键词
妊娠早期
乙肝病毒
艾滋病
梅毒
TORCH
early pregnancy
hepatitis B virus
acquired immunodeficiency syndrome
treponema pallidum
TORCH
