摘要
目的探讨外用维A酸+莫匹罗星治疗复杂性麻风足底溃疡患者对并发症、生活质量及预后的影响。方法采用随机样本抽样法抽取我院2014年1月至2020年4月收取的复杂性麻风足底溃疡患者122例作为研究对象,以随机数字表法分为对照组(n=61)、观察组(n=61),对照组单纯应用莫匹罗星,观察组在此基础上外用维A酸,比较两组临床治疗效果、并发症发生率与病情复发率、治疗前后生活质量评分、治疗前后溃疡面积、疼痛评分、肉芽组织面积。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组并发症总发生率、病情复发率显著低于对照组,差异有统计学意义(P<0.05)。治疗前,两组生活质量评分比较,差异无统计学意义(P>0.05);治疗后,观察组生活质量评分显著高于对照组,差异有统计学意义(P<0.05)。治疗前,两组溃疡面积、肉芽组织面积、疼痛评分比较,差异无统计学意义(P>0.05);治疗后,观察组溃疡面积小于对照组,肉芽组织面积大于对照组,疼痛评分低于对照组,差异有统计学意义(P<0.05)。结论对于复杂型麻风足底溃疡患者,采用维A酸外用+莫匹罗星联合治疗,可显著降低并发症发生率,缩小患者溃疡面积,增加肉芽组织面积,缓解疼痛,提高生活质量,预后较好,临床价值显著,值得进行推广。
Objective To investigate the impacts of topical vitamin A acid combined with mupirocin on complications,quality of life(QoL)and prognosis in the treatment of patients with complex leprosy plantar ulcer.Methods A total of 122 cases of patients with complex leprosy plantar ulcer admitted to our hospital from January 2014 to April 2020 were selected by random sampling method and divided into the control group(n=61)and the observation group(n=61)according to the random number table method.The control group was treated with mupirocin only,while the observation group was treated with vitamin A acid on the basis of mupirocin.The clinical efficacy,incidences of complications and relapse,as well as QoL score,ulcer area,pain score and granulation tissue area before and after treatment were compared between the two groups.Results The total effective rate in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).The total incidences of complications and relapse in the observation group were significantly lower than those in the control group,with statistically significant differences(P<0.05).Before treatment,there was no statistically significant difference in QoL scores between the two groups(P>0.05).After treatment,the QoL score of the observation group was significantly higher than that of the control group,with statistically significant difference(P<0.05).Before treatment,there were no statistically significant differences in ulcer area,granulation tissue area and pain score between the two groups(P>0.05).After treatment,the ulcer area of the observation group was smaller than that of the control group,the granulation tissue area was larger than that of control group,and the pain score of the treatment group was lower than that of the control group,with statistically significant differences(P<0.05).Conclusion For patients with complex leprosy plantar ulcer,the combined treatment of topical vitamin A acid combined with mupirocin can significantly reduce the incidence of complications,reduce the ulcer area of patients,increase the granulation tissue area,relieve pain,improve the QoL,and take good prognosis and significant clinical value,which is worthy of promotion.
作者
黄选利
HUANG Xuanli(Tingliang Hospital of Guangxi Zhuang Autonomous Region,Guangxi,Nanning 530022,China)
出处
《中国医药科学》
2021年第6期79-82,共4页
China Medicine And Pharmacy
关键词
维A酸
莫匹罗星
麻风
足底溃疡
肉芽组织
Vitamin A acid
Mupirocin
Leprosy
Plantar ulcer
Granulation tissue
