摘要
化疗是中晚期恶性肿瘤重要的治疗手段,而耐药形成是限制化疗疗效的棘手问题,中医药在干预耐药形成中发挥着重要作用。化疗后患者常出现虚实寒热错杂的复合证型,而其形成的基础之一阳虚与"癌毒""药毒"互结形成"阳虚毒结"可能是导致化疗耐药的核心机制。分析化疗耐药产生的"阳虚癌毒增殖"与"阳虚药毒不敛"两种演变规律,提出温阳法助机体抵御"药毒"、杀灭"癌毒"和预防转移从而降低耐药发生的机理,以期指导临床恶性肿瘤的治疗。
Chemotherapy is an important treatment method for advanced malignant tumors,however,its effect is limited to the drug resistance which needs to be dealt with.Traditional Chinese medicine(TCM)plays an important role in managing chemotherapy-induced drug resistance.After chemotherapy,the patients often appear mixed deficiency and excess,as well as cold and heat pattern,of which yang deficiency is a pathogenic factor;when yang deficiency is binded with"cancer toxin"and"drug toxin","yang deficiency and toxin accumulation"is formulated and may act as the core mechanism of chemotherapy-induced drug resistance.This paper analyzed the two evolutionary laws of formulation of chemotherapy-induced drug resistance from the theory of"yang deficiency leading to proliferation of cancer toxin"and"yang deficiency leading to astringe of drug toxin".Therefore,Yang-warming method is proposed to help the body to resist"drug toxin",kill"cancer toxin"and prevent metastasis,thereby reducing the mechanism of drug resistance,which can provide guidance for the treatment of malignant tumors in clinical practice.
作者
朱潇雨
吴喆
高瑞柯
张潇潇
李杰
ZHU Xiaoyu;WU Zhe;GAO Ruike;ZHANG Xiaoxiao;LI Jie(Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing,100053)
出处
《中医杂志》
CSCD
北大核心
2021年第8期672-676,共5页
Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81774289)
北京科技计划重大基金(D161100005116004)。
关键词
恶性肿瘤
阳虚毒结
化疗耐药
药毒
malignant tumor
yang deficiency and toxin accumulation
chemotherapy drug resistance
drug toxin
