摘要
目的探讨二至丸加减联合卡托普利治疗顽固性蛋白尿的临床疗效。方法选取崇仁县马鞍镇中心卫生院2017年5月—2020年5月收治的顽固性蛋白尿患者120例,按照入院先后顺序分为对照组与观察组,各60例。对照组予以缬沙坦胶囊治疗,观察组予以二至丸加减联合卡托普利治疗。2组均治疗3周。比较2组临床疗效,治疗前后24 h尿蛋白定量、尿沉渣红细胞计数、中医证候积分,并观察2组不良反应发生情况。结果观察组治疗总有效率高于对照组(P<0.05)。治疗前2组24 h尿蛋白定量、尿沉渣红细胞计数比较,差异无统计学意义(P>0.05);治疗后观察组24 h尿蛋白定量、尿沉渣红细胞计数低于对照组(P<0.05)。治疗前2组腰酸背痛、少气乏力、手足心热、水肿评分比较,差异无统计学意义(P>0.05);治疗后观察组腰酸背痛、少气乏力、手足心热、水肿评分低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论二至丸加减联合卡托普利治疗顽固性蛋白尿的临床疗效确切,可有效降低蛋白尿,缓解临床症状,且安全性较高。
Objective To explore the clinical effect of Erzhi pill combined with captopril on refractory proteinuria.Methods A total of 120 patients with refractory proteinuria were selected from May 2017 to May 2020 in Chongren County Maan Town Center Hospital,which were divided into control group and observation group according to the order of admission,60 cases in each group.The control group was treated with valsartan capsule,the observation group was treated with Erzhi pill combined with captopril.Both groups were treated for 3 weeks.Clinical effect,24-hour urine protein quantification,urine sediment red blood cell count and TCM syndrome integral before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The total effective rate of observation group was higher than control group(P<0.05).Before treatment,there was no significant difference in 24-hour urine protein quantification and urine sediment red blood cell count between the two groups(P>0.05);after treatment,the 24-hour urine protein and urine sediment red blood cell count in the observation group were lower than control group(P<0.05).Before treatment,there was no significant difference in scores of backache,asthenia,hand and foot heart heat and edema between the two groups(P>0.05);after treatment,the scores of backache,asthenia,hand and foot heart heat and edema in the observation group were lower than control group(P<0.05).The incidence rate of adverse reactions in the observation group was lower than control group(P<0.05).Conclusion Erzhi pill combined with captopril have an exact clinical effect for refractory proteinuria,which can effectively reduce proteinuria and relieve clinical symptoms,and with high safety.
作者
邓爱华
DENG Aihua(Chongren County Maan Town Center Hospital,Chongren 344200,China)
出处
《临床合理用药杂志》
2021年第9期37-39,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
顽固性蛋白尿
二至丸
卡托普利
治疗结果
Refractory proteinuria
Erzhi pill
Captopril
Treatment outcome
