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米非司酮对腹腔镜子宫肌瘤剔除术患者复发率、性激素水平与疼痛反应的影响

Effect of Mifepristone on Recurrence Rate,Sex Hormone Level and Pain Response in Patients Undergoing Laparoscopic Myomectomy
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摘要 目的探讨米非司酮对腹腔镜子宫肌瘤剔除术患者复发率、性激素水平及疼痛应激反应的影响。方法选取2019年3月至2020年9月我院收治的82例子宫肌瘤患者,分为研究组与对照组,各41例。对照组行腹腔镜子宫肌瘤剔除术治疗,观察组在对照组基础上在术后再行米非司酮治疗,口服,每日25 mg,每日1次,治疗90 d。比较两组的复发率、性激素水平及疼痛应激反应。结果治疗前,两组FSH、E2、LH水平相比,差异无统计学意义(P>0.05);治疗后,研究组FSH、E2、LH水平均显著高于对照组,组间差异有统计学意义(P<0.05)。治疗前,两组Ang-2、VEGF水平相比,差异无统计学意义(P>0.05);治疗后,研究组Ang-2、VEGF水平均显著低于对照组,组间差异有统计学意义(P<0.05)。研究组术后24 h中度、重度疼痛比例低于对照组(P<0.05);研究组术后72 h中度、重度疼痛比例低于对照组(P<0.05);研究组术后120 h中度、重度疼痛比例低于对照组(P<0.05)。研究组治疗后0.5、1.0、1.5年总复发率低于对照组,组间差异有统计学意义(P<0.05)。结论在子宫肌瘤患者行腹腔镜子宫肌瘤剔除术后再行米非司酮治疗能显著改善患者的性激素水平,降低疼痛程度及复发率,提高患者的生活质量。 Objective To investigate the effect of mifepristone on recurrence rate,sex hormone level and pain stress response in patients with laparoscopic myomectomy.Methods A total of 82 patients with hysteromyoma admitted to our hospital from March 2019 to September 2020 were selected and divided into study group and control group,41 cases in each group.The control group was treated with laparoscopic myomectomy,and the study group was given mifepristone after operation on the basis of the control group.The patients were orally given 25 mg/d,once a day for 90 days.The recurrence rate,sex hormone levels and pain stress response of the two groups were compared.Results Before treatment,there was no statistically significant difference in the levels of FSH,E2 and LH between the two groups(P>0.05);after treatment,the levels of FSH,E2 and LH in the study group were significantly higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).Before treatment,there was no significant difference in Ang-2 and VEGF levels between the two groups(P>0.05);after treatment,the Ang-2 and VEGF levels in the study group were significantly lower than those in the control group,and the difference between the groups was statistically significant(P<0.05).The proportion of moderate and severe pain in the study group was lower than that of the control group at 24 hours after operation(P<0.05);the proportion of moderate and severe pain in the study group was lower than that of the control group at 72 hours after operation(P<0.05);the proportion of moderate and severe pain in the study group was lower than that of the control group at 120 hours after the operation(P<0.05).The total recurrence rate of 0.5,1.0,1.5 years after treatment in the study group was lower than that in the control group,and the difference between the groups was statistically significant(P<0.05).Conclusion Mifepristone treatment after laparoscopic myomectomy can significantly improve the level of sex hormone,reduce the degree of pain and recurrence rate,improve the quality of life of patients.
作者 李桂莲 王园 LI Guilian;WANG Yuan(Department of Obstetrics and Gynecology,Yanggu People's Hospital,Liaocheng 252300,China)
出处 《中国医药指南》 2021年第10期10-12,共3页 Guide of China Medicine
关键词 腹腔镜子宫肌瘤剔除术 米非司酮 复发率 性激素水平 疼痛应激反应 Laparoscopic myomectomy Mifepristone Recurrence rate Sex hormone level Pain stress response
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