摘要
目的探究儿童支气管肺炎实施甲泼尼龙联合阿奇霉素治疗的治疗效果。方法方便选取乐陵市妇幼保健院2019年1月—2020年4月收治的112例支气管肺炎患儿,依据用药方式分为两组,每组56例。参照组应用甲泼尼龙治疗,联合组在参照组基础上联合阿奇霉素治疗,对比分析两组肺功能指标、炎症因子水平、不良反应发生率及治疗总有效率情况。结果治疗前,两组患儿FEV1/FVC、FEV1、FVC及ACT评分对比,差异无统计学意义(P>0.05);治疗后两组患儿均有所改善,联合组FEV1/FVC为(82.84±0.61)%、FEV1为(1.03±0.64)L、FVC为(1.28±0.43)L、ACT评分为(22.63±0.32)分,优于参照组,差异有统计学意义(t=44.847、2.658、2.141、35.236,P<0.05);治疗前,两组患儿中性粒细胞计数、嗜酸性粒细胞计数、IFN-γ、IL-5及IL-4水平差异无统计学意义(P>0.05);治疗后,联合组中性粒细胞计数为(48.20±14.35)×10^(6)/L、嗜酸性粒细胞计数为(8.81±0.33)×10^(6)/L、IFN-γ为(216.54±27.23)ng/L、IL-5为(91.31±17.21)ng/L、IL-4为(107.82±24.36)ng/L,优于参照组,组间差异有统计学意义(t=4.700、27.157、10.536、9.698、29.124,P<0.05);联合组不良反应发生率为5.36%,参照组为7.14%,组间差异有统计学意义(χ^(2)=0.000,P>0.05);联合组治疗总有效率为92.86%,参照组为78.57%,组间差异有统计学意义(χ^(2)=4.667,P<0.05)。结论儿童支气管肺炎患儿应用甲泼尼龙联合阿奇霉素治疗可有效改善患儿肺功能,减少炎症反应发生,安全性高,效果较好。
Objective To explore the therapeutic effect of methylprednisolone combined with azithromycin in children with bronchopneumonia.Methods A total of 112 children with bronchial pneumonia admitted to the Leling maternity and child health hospital from January 2019 to April 2020 were conveniently selected and divided into two groups according to the way of medication,with 56 cases in each group on the basis of the reference group.The reference group was treated with methylprednisolone,and the combination group was treated with azithromycin.The lung function indexes,inflammatory factor levels,incidence of adverse reactions and the total effective rate of treatment were compared and analyzed in the two groups.Results Before treatment,there was no statistically significant difference in FEV1/FVC,FEV1,FVC and ACT scores between the two groups of children(P>0.05);after treatment,both groups of children improved,and the FEV1/FVC of the combination group was(82.84±0.61)%,FEV1 was(1.03±0.64)L,FVC was(1.28±0.43)L,ACT score was(22.63±0.32)points,which were better than the reference group,the difference was statistically significant(t=44.847,2.658,2.141,35.236,P<0.05);before treatment,there was no statistically significant difference in neutrophil count,eosinophil count,IFN-γ,IL-5 and IL-4 levels between the two groups of children(P>0.05).After treatment,the comblination group reduced the neutrophil count to(48.20±14.35)×10^(6)/L,the eosinophil count to(8.81±0.33)×10^(6)/L,and IFN-γto(216.54±27.23)ng/L,IL-5 was(91.31±17.21)ng/L,IL-4 was(107.82±24.36)ng/L,which were better than the reference group,the difference between the groups was statistically significant(t=4.700,27.157,10.536,9.698,29.124,P<0.05);the incidence of adverse reactions in the combination group was 5.36%,and the reference group was 7.14%,the difference between the groups was statistically significant(χ^(2)=0.000,P>0.05);the total effective rate of the treatment in the combination group was 92.86%,the reference group was 78.57%,and the difference between the groups was statistically significant(χ^(2)=4.667,P<0.05).Conclusion The treatment of children with bronchial pneumonia with methylprednisolone combined with azithromycin can effectively improve the lung function of children,reduce the occurrence of inflammation,and has high safety and good results.
作者
邱明明
QIU Mingming(Department of Pediatrics,Maternal and Child Health Hospital of Leling City,Leling,Shandong Province,235600 China)
出处
《中外医疗》
2021年第10期97-100,共4页
China & Foreign Medical Treatment
关键词
甲泼尼龙
阿奇霉素
支气管肺炎
肺功能
免疫因子
Methylprednisolone
Azithromycin
Bronchopneumonia
Lung function
Immune factors
