摘要
雷公藤甲素(Triptolide,TP)是来源于药用植物雷公藤Tripterygium wilfordii Hook F的一种天然三环氧二萜。作为雷公藤的高活性成分之一,TP具有抗炎、免疫抑制、抗肿瘤等多种药理作用。该文综述了雷公藤甲素在抗肿瘤方面的作用机制及其在发挥作用时导致的毒性作用,并从中药配伍角度提出了减毒的解决方法,以期为雷公藤甲素及其相关衍生物的临床开发提供参考。
Triptolide(TP)is a kind of natural triepoxide diterpenoid,isolated from Chinese medical herb Tripterygium wilfordii Hook F.As one of the primary biologically active ingredients,TP possesses various and potent pharmacological effects such as anti-inflammatory,immunosuppressive and anti-tumor properties.Here,we focus on the mechanisms of actions of TP in anti-tumor effects,the toxicity and the possible solutions in toxicity attenuation by compatibility.This review may provide reference for the clinical development of TP as well as its related derivatives.
作者
宋祎
刘琰
方冰倩
康迪
胡立宏
SONG Yi;LIU Yan;FANG Bing-qian;KANG Di;HU Li-hong(Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, China)
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2021年第3期457-464,共8页
Journal of Nanjing University of Traditional Chinese Medicine
基金
江苏省研究生实践创新计划项目(SJCX20_0534)。
关键词
雷公藤甲素
抗肿瘤作用
配伍减毒
triptolide
mechanism of anti-cancer
toxicity attenuation by compatibility
