摘要
目的分析慢性阻塞性肺疾病(慢阻肺)急性加重期治疗中糖皮质激素联合特布他林的治疗效果。方法 100例慢阻肺急性加重期患者,随机分为观察组与对照组,每组50例。对照组进行糖皮质激素治疗,观察组实施糖皮质激素联合特布他林治疗。比较两组患者临床疗效、肺功能指标[第1秒用力呼气容积(FEV1)、用力呼气容积(FVC)、呼气峰流速(PEF)]。结果观察组患者的治疗总有效率96%(48/50)显著高于对照组的82%(41/50),差异具有统计学意义(P<0.05)。观察组患者的FEV1(2.92±0.12)L、FVC(3.69±0.07)L、PEF(3.19±0.5)L/s均显著高于对照组的(2.06±0.41)L、(2.72±0.10)L、(2.87±0.39)L/s,差异具有统计学意义(P<0.05)。结论在慢阻肺急性加重期治疗中应用糖皮质激素联合特布他林,具有显著效果,能够有效改善患者的肺功能,具有临床推广应用价值。
Objective To analyze the therapeutic effect of glucocorticoid combined with terbutaline in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods A total of 100 patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into observation group and control group,with 50 cases in each group.The control group was treated with glucocorticoid,and the observation group was treated with glucocorticoid and terbutaline.The clinical efficacy,and pulmonary function indicators[forced expiratory volume in the first second(FEV1),forced vital volume(FVC),peak expiratory flow rate(PEF)]were compared between the two groups.Results The total effective rate 96%(48/50)of the observation group was significantly higher than 82%(41/50)of the control group,and the difference was statistically significant(P<0.05).The FEV1(2.92±0.12)L,FVC(3.69±0.07)L and PEF(3.19±0.5)L/s of the observation group were significantly higher than(2.06±0.41)L,(2.72±0.10)L and(2.87±0.39)L/s of the control group,and the difference was statistically significant(P<0.05).Conclusion Combination of glucocorticoid and terbutaline shows remarkable effect on acute exacerbation of chronic obstructive pulmonary disease,and it can effectively improve the pulmonary function of patients.It contains clinical promotion and application value.
作者
胡冬峰
HU Dong-feng(Nansun Hospital of Gaoli Street,Weifang 261104,China)
出处
《中国实用医药》
2021年第13期146-149,共4页
China Practical Medicine
关键词
糖皮质激素
特布他林
慢性阻塞性肺疾病急性加重期
Glucocorticoid
Terbutaline
Acute exacerbation of chronic obstructive pulmonary disease
