摘要
目的通过对数据挖掘这一技术的有效利用,进一步就强直性脊柱炎治疗过程之中补虚活血膏方的用药规律开展针对性研究并加以总结,在此基础上,进而对新组方进行探索,以提供中医药治疗的新思路。方法收集2016年7月—2019年3月期间在上海中医药大学附属龙华医院、岳阳中西医结合医院、光华中西医结合医院风湿科门诊和住院病房收治的强直性脊柱炎(Ankylosing Spondylitis,AS)患者所使用的膏方,共获取157首膏方,通过对中医传承辅助平台(V2.5)的有效利用,实现膏方数据库的构建,并以软件为依托,运用其中关联规则分析与复杂系统熵聚类等方式,对膏方加以研究与分析。结果经软件分析得出补虚活血膏方治疗强直性脊柱炎的高频药物有熟地黄、鸡血藤、女贞子、续断以及桑寄生等20味药;通过对这些药物进行四气五味分析发现:在四气方面,使用频率最高的主要以温性药物为主,其使用频率超过50%,使用频率最低的则是热性药物;在五味方面,使用频率最高的主要以苦味、辛味、甘味药物为主,其使用频率超过40%,与此同时,使用频率最低的则是涩味药物;在使用归经分析这些药物中,依次归于肝经(1205次)、肾经(890)以及脾经(791);加强中药关联组合11个,形成新核心组合10个。结论补虚活血膏方在进行AS的治疗过程中,将扶正与化瘀紧密结合在一起,形成以补益肝肾、强壮筋骨为主,佐以祛风除湿、活血化瘀的治疗原则,对减轻患者的临床症状、提高机体免疫力,发挥了较好的治疗效果。
Objective Through the effective use of data mining technology,to further carry out targeted research and summarize the prescription of the prescription of tonifying and activating blood in the treatment of ankylosing spondylitis,and on this basis,to explore the new prescription To provide new ideas for Chinese medicine treatment.Methods Collected the ointments used by AS patients who were admitted to the outpatient and inpatient wards of the rheumatism department of the Shanghai University of Traditional Chinese Medicine Longhua Hospital,Yueyang Integrated Traditional Chinese and Western Medicine Hospital,and Guanghua Integrated Traditional Chinese and Western Medicine Hospital from July2016 to March 2019.Acquire 157 first ointment recipes,realize the construction of the ointment recipe database through the effective use of the traditional Chinese medicine inheritance auxiliary platform(V2.5),and rely on software,use the methods of association rule analysis and complex system entropy clustering,etc.Fang to conduct research and analysis.Results After software analysis,it was concluded that the high-frequency medications for the treatment of ankylosing spondylitis with Buxuhuoxue Ointment included Rehmannia glutinosa,Caulis spatholobi,Ligustrum lucidum,Dipsacus and Morus sinensis,etc.20 herbs;The analysis found that:in terms of the four qi,the most frequently used drugs are mainly warm drugs,whose use frequency exceeds 50%,and the least frequently used are thermal drugs;in terms of five flavors,the most frequently used ones are mainly bitter and pungent.,Sweet medicines are the main ones,and their use frequency exceeds40%.At the same time,the astringent medicines are the least frequently used.In the analysis of the use of the meridian,these drugs are classified in the liver meridian(1205 times),kidney meridian(890 times) and the spleen meridian(791 times);11 strengthened Chinese medicine related combinations,forming 10 new core combinations.Conclusion The treatment of AS is based on the principles of tonifying the liver and kidney,strengthening the tendons and bones,dispelling wind and dehumidifying,and promoting blood circulation and removing blood stasis,which has played a better therapeutic effect on reducing the clinical symptoms of patients and improving the immunity of the body.
作者
杨晔颖
何东仪
薛鸾
朱琦
于盈盈
程鹏
孙宇
苏励
YANG Ye-ying;HE Dong-yi;XUE Luan;ZHU Qi;YU Ying-ying;CHENG Peng;SUN Yu;SU Li(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032;Shanghai Guanghua Hospital,Shanghai 200052;Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437;Shanghai Qingpu Traditional Chinese Medicine Hospital,Shanghai 201400)
出处
《世界中西医结合杂志》
2021年第3期429-434,共6页
World Journal of Integrated Traditional and Western Medicine
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015193)。
关键词
强直性脊柱炎
补虚活血膏方
数据挖掘
用药规律
Ankylosing Spondylitis
Nourishing And Activating Blood Ointment Prescription
Data Mining Technology
Medication Law
