摘要
目的盐酸坦索罗辛缓释胶囊与尿石通丸对输尿管结石碎石术后辅助排石及炎症因子的临床疗效分析。方法选取自2018年6月-2019年12月医院泌尿外科就诊的80例输尿管结石患者为研究对象,用随机数字表法将80例患者随机分为对照组(盐酸坦索罗辛缓释胶囊)和治疗组(盐酸坦索罗辛缓释胶囊联合尿石通丸),每组40例。两组患者均从术后开始服药,连续服用14 d,观察两组患者术后第7天和第14天结石排净率、术后肾绞痛复发率、止痛剂使用率以及二次碎石率,术前及术后VAS疼痛评分,术后当天即术后3 d血清炎症因子以及不良反应发生率。结果治疗组患者术后总有效率为97.5%(39/40),与对照组比较差异有统计学意义(P<0.05),治疗组患者在结石排净率、肾绞痛复发率、止痛剂使用率和二次碎石率均优于对照组,差异有统计学意义(P<0.05),治疗组患者术后的VAS疼痛评分明显低于对照组,差异有统计学意义(P<0.05)。在术后当天,对照组和治疗组hs-CRP、IL-6、TNF-α3个指标较术前均明显升高,差异有统计学意义(P<0.01),在术后3 d,治疗组炎症因子较对照组明显下降,差异有统计学意义(P<0.05)。治疗组和对照组在不良反应发生率方面差异无统计学意义。结论盐酸坦索罗辛缓释胶囊联合尿石通丸对于输尿管结石碎石术后的患者可以加速结石排出,减少肾绞痛复发率以及止痛剂使用率,降低体内微炎症反应,而且不良反应轻微,具有一定的临床应用价值。
Objective To analyze the effect of Tamsulosin Hydrochloride Sustained Release Capsule and Niaoshitong Pill(尿石通丸)on stone removing and inflammatory cytokines after ureteral lithotripsy.Methods Eighty patients with ureteral calculi who visited the department of urology in our hospital were selected as the study objects from June 2018 to December 2019.The patients were randomly divided into the control group(Tarsolosin Hydrochloride Sustained Release Capsule)and the treatment group(Tarsolosin Hydrochloride Sustained Release Capsule combined with Niaoshitong Pill)with random number table method,with 40 patients in each group.All the patients took medicine for 14 days after operation.The stone clearance rate,renal colic recurrence rate,analgesic use rate,secondary lithotripsy rate,VAS pain score before and after operation and the incidence of adverse reactions were observed 7 and 14 days after operation.The serum inflammatory cytokines were tested on the same day and 3 day after operation.Results The effective rate of treatment group was 97.5%(39/40).There was statistically significant difference compared with that of the control group(P<0.05).The stone-free rate,renal colic,analgesic usage and secondary debris in the treatment group were better than those of the control group and the difference was statistically significant(P<0.05).The postoperative VAS score in the treatment group was improved significantly than that of the control group and the difference was statistically significant(P<0.05).On the day after the operation,levels of hs-CRP,IL-6 and TNF-αin the control group and the treatment group were significantly higher than those before operation(P<0.01).Three days after the operation,the inflammatory indicators in the treatment group were significantly lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups.Conclusion The combination of Tamsulosin Hydrochloride Sustained Release Capsule and Niaoshitong Pill can accelerate the expulsion of calculi,reduce the recurrence rate of renal colic and the use rate of analgesics,and reduce the micro-inflammatory reaction in the patients after ureteral lithotripsy,which has certain clinical application value.
作者
申绯翡
石红林
SHEN Feifei;SHI Honglin(Department of Medical Laboratory Technology of Luoyang Polytechnic,Lnoyang 471000,Henan,China;Henan People's Hospital,Zhengzhou 450000,Henan,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第3期251-254,共4页
Chinese Archives of Traditional Chinese Medicine
基金
河南省科技攻关项目(162102310172)。
关键词
盐酸坦索罗辛缓释胶囊
尿石通丸
输尿管结石
体外碎石
炎症因子
Tamsulosin Hydrochloride Sustained Release Capsule
Niaoshitong Pill(尿石通丸)
ureteral calculi
extracorporeal lithotripsy
inflammatory cytokines
