摘要
骨折愈合是一个复杂的生物学过程,骨折后在损伤部位首先会形成血肿,免疫细胞和炎症因子便迅速到达骨折部位,以利于骨组织的修复和重建。免疫细胞和炎症因子是机体免疫系统的重要组成部分,而免疫系统对清除坏死组织和维持机体内环境稳态起关键作用。骨折后如果免疫调节得当,则对骨折愈合有益;如果免疫调节不得当,骨折部位则逐渐发展成为慢性炎症状态反而可能会损害愈合。笔者就先天免疫系统和适应性免疫系统在骨折愈合中的作用机制以及免疫调节药物影响免疫系统状态从而影响骨折愈合的研究进展进行综述,为临床治疗骨折提供新思路。
Fracture healing is a complex biological process.After a fracture,a hematoma will first form at the injured site,and immune cells and inflammatory factors will quickly reach the fracture site to facilitate the repair and reconstruction of bone tissue.Immune cells and inflammatory factors are an important part of the body's immune system,and the immune system plays a key role in removing necrotic tissue and maintaining the hom eostasis of the body's environment.Proper immune regulation after a frac ture is beneficial to fracture healing;if immune regulation is im proper,the fracture site will giadually develop into a chronic inflammatory state,which may impair healing.The authors summarize the mechanism of action of the innate immune system and adaptive immune system in fracture healing,as well as the research progress of therapeutic drugs that affect the state of the immune system and thus affect the healing of fractures,so as to deepen the understanding of the immune system affecting bone regeneration and provide new ideas for clinical treatm ent of fracture.
作者
秦明明
张晶晶
冯浩
王磊
Qin Mingming;Zhang Jingjing;Feng Hao;Wang Lei(Department of Orthopedics,Central Hospital of Ningcheng County,Inner Mongolia Autonomous Region,Chifeng 024200,China;Chifeng Hospital,Inner Mongolia Autorwmoiis Region/Central Laboratory of Chifeng Clinical School of Inner Mongolia Medical University,Chifeng 024000,China;Chifeng Hospital,Inner Mongolia Autonomous Region/Clinical Ldboratory Center,Chifeng Clinical School of Inner Mongolia Medical University,Chifeng 024000,China)
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2021年第5期473-480,共8页
Chinese Journal of Trauma
关键词
骨折
免疫
细胞
骨折愈合
炎症因子
Fractures,hone
Immunity,cellular
Fracture healing
Inflammatory factors
