摘要
目的观察早发型重度子痫前期低分子量肝素联合小剂量阿司匹林治疗的效果。方法回顾性分析2019年10月至2020年10月同济大学附属第一妇婴保健院早发型重度子痫前期孕妇100例,根据治疗方法分为常规治疗组与常规治疗基础上应用低分子量肝素联合小剂量阿司匹林的联合治疗组,每组各50例,比较分析两组患者的血压水平、凝血功能、妊娠结局、产后出血量、复发情况。结果两组治疗前的舒张压、收缩压、凝血酶原时间、凝血活酶时间、血小板计数、纤维蛋白原比较差异均无显著性(P>0.05),治疗后舒张压、收缩压、血小板计数、纤维蛋白原均较治疗前显著降低,且联合治疗组低于常规治疗组,治疗后凝血酶原时间、凝血活酶时间均显著延长,且联合治疗组凝血酶原时间、凝血活酶时间长于常规治疗组,差异均有显著性(P<0.05)。联合治疗组的产后出血、胎盘早剥、胎儿窘迫、胎儿生长受限、新生儿死亡发生率及复发率均低于常规治疗组,产后出血量少于常规治疗组,差异均有显著性(P<0.05)。结论早发型重度子痫前期低分子量肝素联合小剂量阿司匹林治疗的效果好。
Objective To observe the effect of low molecular weight heparin combined with low-dose aspirin in the treatment of earlyonset severe preeclampsia.Method 100 cases of pregnant women with early onset severe preeclampsia in our hospital from October 2019 to October 2020 were selected retrospectively.According to the treatment methods,they were divided into conventional treatment group and low molecular weight heparin combined with low dose aspirin treatment group(combined treatment group),with 50 cases in each group.The blood pressures,coagulation functions,pregnancy outcomes,postpartum hemorrhage and recurrences of the two groups were statistically analyzed.Result The decreases of diastolic blood pressure and systolic blood pressure in the combined treatment group were significantly higher than the conventional treatment group(P<0.05).The increases of PT,APTT,decreases of PLT and FIB levels of the combined treatment group were significantly higher than the conventional treatment group(P<0.05).The incidences of postpartum hemorrhage,placental abruption,fetal distress,fetal growth restriction and neonatal death in the combined treatment group were significantly lower than the conventional treatment group(P<0.05).The amount of postpartum hemorrhage in the combined treatment group was significantly less than the conventional treatment group(P<0.05),the recurrence rate was significantly lower than in the conventional treatment group(P<0.05).Conclusion Low molecular weight heparin combined with low-dose aspirin has good effect in the treatment of early onset severe preeclampsia.
作者
金依华
厉跃红
姚微微
Jin Yihua;Li Yuehong;Yao Weiwei(Department of Obstetrics,First Maternal and Child Health Hospital Affiliated to Tongji University,Shanghai 201204,China)
出处
《中国医刊》
CAS
2021年第6期630-632,共3页
Chinese Journal of Medicine
关键词
早发型重度子痫前期
低分子量肝素
小剂量阿司匹林
复发
血压
凝血功能
妊娠结局
产后出血
Early onset severe preeclampsia
Low molecular weight heparin
Low dose aspirin
Recurrence
Blood pressure
Coagulation function
Pregnancy outcome
Postpartum hemorrhage
