摘要
目的系统评价补肾活血中药单独使用或和西医疗法联合使用对比单纯西医疗法治疗薄型子宫内膜的疗效。方法计算机检索知网数据库、维普网、万方数据知识服务平台等中文科技期刊数据库,时间限定为从2010年1月—2020年1月,检索补肾活血中药单独使用或和西医疗法联合使用改善薄型子宫内膜疗效的随机对照试验(RCT),采用Rev Man5.3软件进行Meta分析。结果共有13项RCT符合纳入标准,合计1062例薄型子宫内膜患者。本次Meta分析结果显示:补肾活血中药单独使用或和西医疗法联合使用对比单纯西医疗法在临床总有效率[RR=1.18,95%CI(1.06,1.30),P=0.001<0.05]、增加子宫内膜厚度[WMD=-1.17,95%CI(-1.33,-1.00),P<0.00001]、增加A型子宫内膜比例[RR=1.70,95%CI(1.38,2.10),P<0.00001]、妊娠率[RR=1.61,95%CI(1.36,1.91),P<0.00001]、子宫动脉阻力指数(RI)[WMD=-0.12,95%CI(-0.17,-0.07),P<0.00001]、子宫动脉搏动指数(PI)[WMD=-0.26,95%CI(-0.37,-0.15),P<0.00001]方面,差异有统计学意义。结论补肾活血中药单用或和西医疗法联用能有效改善薄型子宫内膜患者的临床总有效率,增加子宫内膜厚度,提高A型子宫内膜类型的比例,从厚度及形态上改善子宫内膜环境,降低子宫动脉搏动指数及阻力指数,进而改善子宫动脉血流灌注,提高子宫内膜容受性及临床妊娠率,有望进一步临床推广。
Objective To systematically evaluate the efficacy of tonifying kidney and activating blood Chinese drugs alone or combined with western medicine in the treatment of thin endometrium.Methods By computer retrieval,CNKI,VIP and WanFang were searched and the time limit was from January 2010 to January 2020.RCTs about tonifying kidney and activating blood Chinese drugs used alone or in combination with western medicine treatment for thin endometrium were collected and analyzed by using Rev Man 5.3 software.Results A total of 13 RCTs met the inclusion criteria,with a total of 1062 patients with thin endometrium.The results of this Meta-analysis showed that: onifying kidney and activating blood Chinese drugs used alone or in combination with western medicine therapy had statistical significance in the clinical total effective rate(RR = 1.18,95% CI(1.06,1.30),P = 0.001 < 0.05],increasing endometrial thickness[WMD = 1.17,95% CI(1.33,1.00),P <0.00 001) and increasing the proportion of type A endometrial[RR = 1.70,95% CI(1.38,2.10),P < 0.00 001),pregnancy rate(RR = 1.61,95% CI(1.36,1.91).P < 0.00 001 ],uterine artery resistance index(RI) [WMD =-0.12,95% CI(-0.17,-0.07),P < 0.00 001]and uterine artery pulse index(PI) [WMD =-0.26,95% CI(-0.37,-0.15),P <0.00 001] compared with western medicine alone.Conclusion Tonifying kidney and activating blood Chinese drugs alone or combined with western medicine therapy can effectively improve the clinical total effective rate of thin endometrium,increase the proportion of type A endometrial type,improve the endometrial environment from the thickness and morphology,reduce the uterine artery pulsation index and resistance index,and then improve the uterine artery blood flow perfusion,endometrial receptive and clinical pregnancy rate.It is expected to further clinical promotion.
作者
伍娟娟
严斯琪
刘锐
WU Juanjuan;YAN Siqi;LIU Rui(Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine,Nanning 530011,Guangxi,China;Guangxi University of Chinese Medicine,Nanning 530011,Guangxi,China)
出处
《实用中医内科杂志》
2021年第3期54-59,共6页
Journal of Practical Traditional Chinese Internal Medicine
基金
广西自然科学基金(2017GXNSFBA198109)。
关键词
补肾活血中药
薄型子宫内膜
META分析
tonifying kidney and activating blood Chinese drugs
thin endometrium
Meta-analysis
