摘要
目的:探讨结直肠癌组织中泛醌-细胞色素c还原酶复合物核心蛋白1(UQCRC1)的表达及其与血清癌胚抗原(CEA)的相关性。方法:收集52例结直肠癌组织蜡块及37例癌旁组织蜡块,采用免疫组化SP法检测UQCRC1的表达水平,分析其表达与结直肠癌临床病理特征以及血清CEA值的相关性。结果:UQCRC1在癌组织中表达下调率为30.8%,在癌旁正常组织中表达下调率为10.8%,两者差异有统计学意义(χ2=4.94,P<0.05)。且其表达与结直肠癌淋巴结转移有关,伴有淋巴结转移的病人阴性表达率(45.5%)高于不伴有淋巴有转移的病人(20.0%),两者差异有统计学意义(P<0.05);癌组织中UQCRC1表达与术前血清CEA水平呈负相关(r=-0.300,P<0.05)。结论:UQCRC1在结直肠癌中的表达下调在肿瘤发生、发展中发挥重要作用,联合血清CEA可为结直肠癌的病情评估提供理论依据。
Objective:To investigate the expression levels of ubiquinol cytochrome c reductase core protein 1(UQCRC1)in colorectal cancer tissues,and its correlation with serum carcinoembryonic antigen(CEA)level.Methods:The expression levels of UQCRC1 in 52 cases of colorectal cancer tissue and 37 cases of paracancer tissue were detected using the immunochemistry SP method,and the relationship between the expression levels of UQCRC1,and clinicological characteristics of colorectal cancer and serum level of CEA were analyzed.Results:The down-regulation rates of UQCRC1 in cancer tissue and normal tissue adjacent to cancer were 30.8%and 10.8%,respectively,and the difference of which was statistically significant(χ2=4.94,P<0.05).The UQCRC1 expression was related to lymph node metastasis of colorectal cancer,and the negative expression rate in patients with lymph node metastasis(45.5%)was higher than that in patients without lymph node metastasis(20.0%)(P<0.05).The UQCRC1 expression in cancer tissue was negatively correlated with the preoperative serum CEA level(r=-0.300,P<0.05).Conclusions:The down-regulation of UQCRC1 expression in colorectal cancer may play an important role in tumorigenesis and development,and UQCRC1 combined with serum CEA can provide the theoretical basis in the assessment of colorectal cancer.
作者
娄诗涵
汪强武
郑海伦
LOU Shi-han;WANG Qiang-wu;ZHENG Hai-lun(Department of Gastroenterology,The First Affiliated Hospital of Bengbu Medical College,Bengbu Anhui 233004,China)
出处
《蚌埠医学院学报》
CAS
2021年第4期436-439,共4页
Journal of Bengbu Medical College
基金
安徽省自然科学基金资助项目(1808085MH240)。
