摘要
Objective:To explore the main pathways and possible mechanisms of lonicera Japonica and forsythia in the treatment of COVID-19 using network pharmacology.Methods:The TCMSP database,GeneCards,Uniprot,DAVID and othe1databases and Cytoscape software were used to build an interaction network and analyze GO biological processes and KEGG metabolic pathways.Results:A total of 26 lonicera Japonica-forsythia drugs were used to treat COVID-19,mainly through multiple pathways such as cancer pathway,tuberculosis,influenza A,hepatitis B,TNF signaling pathway and HIF-1 signaling pathway Participate in the treatment of COVID-19.Conclusion:The working mechanism of action of lonicera Japonica-forsythia medicine on the treatment of COVID-19 mainly reflects the regulation of cell apoptosis and gene expression,inhibition of viral replication,bacteriostatic and immunomodulation,etc.,providing relevant theoretical basis for the clinical treatment of COVID-19.
基金
National key R&D project of Traditional Chinese medicine modernization(No.2019YFC1709300)。
