摘要
目的探讨双歧杆菌三联活菌散治疗儿童腹型过敏性紫癜(AP)的临床疗效。方法选取郴州市第一人民医院2017年11月—2019年10月收治的腹型AP患儿94例,随机分为对照组与观察组,各47例。对照组予以常规治疗,观察组在对照组基础上予以双歧杆菌三联活菌散治疗。比较2组临床疗效,治疗前后血清脂肪酶(LPS)、降钙素原(PCT)和肿瘤坏死因子α(TNF-α),并观察2组不良反应发生情况。结果观察组临床疗效优于对照组(P<0.05)。治疗前,2组LPS、PTC和TNF-α比较,差异无统计学意义(P>0.05);治疗后,观察组LPS、PTC和TNF-α低于对照组(P<0.05)。观察组不良反应发生率低于对照组(P<0.05)。结论双歧杆菌三联活菌散治疗儿童腹型AP的临床疗效确切,可有效改善患儿症状,重建肠道微生物系统环境平衡,促进肠道黏膜屏障功能恢复,且安全性较高。
Objective To explore the clinical effect of bifidobacterium triple viable powder on children with abdominal allergic purpura(AP).Methods A total of 94 children with AP were selected from November 2017 to October 2019 in Chenzhou First People’s Hospital,which were randomly divided into control group and observation group,47 cases in each group.The control group was given routine treatment,the observation group was treated with bifidobacterium triple viable bacteria powder on the basis of the control group.Clinical effect,LPS,PCT and TNF-αbefore and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The clinical effect of the observation group was better than control group(P<0.05).Before treatment,there was no significant difference in LPS,PTC and TNF-αbetween the two groups(P>0.05);after treatment,LPS,PTC and TNF-αin the observation group were lower than control group(P<0.05).The incidence of adverse reactions in the observation group was lower than control group(P<0.05).Conclusion Bifidobacterium triple viable powder have an exact clinical effect for children with abdominal allergic purpura,it can effectively improve the symptoms of children,rebuild the environmental balance of intestinal microbial system and promote the recovery of intestinal mucosal barrier function,and with high safety.
作者
吴海燕
WU Haiyan(Chenzhou First People’s Hospital,Chenzhou 423000,China)
出处
《临床合理用药杂志》
2021年第12期53-55,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
腹型过敏性紫癜
儿童
双歧杆菌三联活菌散
治疗结果
Abdominal anaphylactoid purpura
Children
Bifidobacterium triple viable bacteria powder
Treatment outcome
