摘要
目的分析胰岛素抵抗、肥胖及性激素水平与多囊卵巢综合征(PCOS)患者血清抗苗勒管激素(AMH)水平的相关性。方法选取2017年9月-2019年8月收治的118例PCOS患者为观察组,同期收治的50例卵巢功能正常的有生育需要的妇女为对照组。检测血清性激素、空腹血糖(FPG)及空腹胰岛素(FINS)水平。根据体质指数(BMI),将观察组患者分为肥胖和非肥胖两个亚组;根据HOMA-IR,将观察组患者分为胰岛素抵抗与非胰岛素抵抗两个亚组。分析PCOS患者血清AMH水平与胰岛素抵抗、肥胖、性激素指标的相关性。结果与非肥胖亚组比较,肥胖亚组血清AMH、黄体生成素(LH)、FPG、FINS水平和HOMA-IR明显更高(均P<0.05)。与非胰岛素抵抗亚组比较,胰岛素抵抗亚组血清AMH、LH、FPG、FINS水平明显更高(均P<0.05)。Pearson相关分析结果显示:PCOS患者的血清AMH水平与BMI无相关性,与HOMA-IR、血清LH水平均呈正相关。结论PCOS患者的血清AMH水平明显上升,胰岛素抵抗发生率较高,血清AMH水平与胰岛素抵抗、血清LH水平均显著相关,但与肥胖无显著相关性。
Objective To analyze the correlations between insulin resistance,obesity,levels of sex hormones and serum anti-Müllerian hormone(AMH)in patients with polycystic ovary syndrome(PCOS).Methods From September 2017 to August 2019,118 patients with PCOS were selected as observation group,50 women with normal ovarian function and birth demand were selected as control group.The levels of serum sex hormones,fasting plasma glucose(FPG),and fasting insulin(FINS)were detected.According to body mass index(BMI),the patients in observation group were divided into obesity subgroup and non-obesity subgroup;according to HOMA-IR,the patients in observation group were divided into insulin resistance subgroup and non-insulin resistance subgroup.The correlations between serum AMH level and insulin resistance,obesity,sex hormones were analyzed.Results Compared with non-obesity subgroup;the levels of serum AMH,luteinizing hormone(LH),FPG,FINS,and HOMA-IR in obesity subgroup increased significantly(P<0.05).Compared with non-insulin resistance subgroup,the levels of serum AMH,LH,FPG,and FINS in insulin resistance subgroup increased significantly(P<0.05).Pearson correlation analysis showed that there was no correlation between serum AMH level and BMI in PCOS patients,serum AMH level was positively correlated with HOMA-IR and serum LH level.Conclusion The levels of serum AMH in PCOS patients increase significantly,the incidence rate of insulin resistance is high,serum AMH level is significantly correlated with insulin resistance and serum LH level,but it is not correlated with obesity.
作者
董金凤
蒋晶
郑彤彤
赵帼娣
李素琴
DONG Jin-Feng;JIANG Jing;ZHENG Tong-Tong(Department of Maternal Health Care and Family Planning,Yuhuan Municipal Maternal and Child Health Care Hospital,Yuhuan,Zhejiang 317600,China;不详)
出处
《中国妇幼保健》
CAS
2021年第9期2086-2089,共4页
Maternal and Child Health Care of China
基金
玉环市科技计划项目(2018067)。
关键词
多囊卵巢综合征
抗苗勒管激素
胰岛素抵抗
肥胖
性激素
相关性
Polycystic ovary syndrome
Anti-Müllerian hormone
Insulin resistance
Obesity
Sex hormone
Correlation
