摘要
【目的】探究加减龙胆泻肝汤对原发性肝癌肝动脉化疗栓塞术(TACE)后栓塞综合征肝经热毒证患者肝功能和生活质量的影响。【方法】将82例原发性肝癌TACE术后栓塞综合征肝经热毒证患者随机分为研究组和对照组,每组各41例。对照组患者术后给予常规西医对症治疗,研究组患者在对照组基础上联合加减龙胆泻肝汤治疗,疗程为2周。观察2组患者的发热、恶心、呕吐、便秘、肝区疼痛等临床症状持续时间,以及治疗前后肝功能指标[谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)、白蛋白(ALB)]和生活质量卡氏功能状态(KPS)评分的变化情况。【结果】(1)研究组患者的发热、恶心、呕吐、便秘、肝区疼痛等临床症状的持续时间均明显短于对照组,差异均有统计学意义(P<0.05)。(2)治疗后,2组患者的肝功能指标ALT、AST、GGT、ALB水平均较治疗前明显降低(P<0.05),且研究组的降低作用均明显优于对照组,差异均有统计学意义(P<0.05)。(3)治疗1周和2周后,2组患者的生活质量KPS评分均较治疗前明显提高(P<0.05),且研究组的提高作用均明显优于对照组,差异均有统计学意义(P<0.05)。【结论】对原发性肝癌TACE术后栓塞综合征肝经热毒证患者使用加减龙胆泻肝汤治疗,可有效缩短患者的临床症状持续时间,改善患者的肝功能指标,提高患者的生活质量评分,具有较高的临床应用价值。
Objective To investigate the effect of modified Longdan Xiegan Decoction on liver function and quality of life in primary liver cancer patients with embolism syndrome after transcatheter arterial chemoembolization(TACE) and differentiated as the syndrome of heat toxin in liver meridian.Methods A total of 82 primary hepatocellular carcinoma patients with embolism syndrome after TACE were randomized into study group and control group,and each group had 41 patients.The control group was given symptomatic treatment by routine western medicine after operation,while the study group was treated with Longdan Xiegan Decoction on the basis of treatment for the control group.The two groups were treated for 2 weeks.The duration of clinical symptoms of fever,nausea,vomiting,constipation,and pain in the hepatic region of the two groups was observed.And before and after treatment,the changes in the liver function indexes of alanine transaminase(ALT),aspartate transaminase(AST),gamma-glutamyl transpeptidase(GGT),and albumin(ALB) as well as the Karnofsky Performance Status(KPS)scores for the quality of life in the two groups were observed.Results (1)The duration of clinical symptoms of fever,nausea,vomiting,constipation and pain in hepatic region in the study group was significantly shorter than that in the control group,the difference being statistically significant(P<0.05)(2)After treatment,the levels of the liver function indexes of ALT,AST,GGT and ALB in the two groups were significantly decreased(P<0.05 in comparison with those before treatment),and the decrease in the study group was superior to that in the control group,the difference being statistically significant(P<0.05).(3)After treatment for one week and 2 weeks,KPS scores of the quality of life in the two groups were significantly increased(P<0.05 in comparison with those before treatment),and the increase in the study group was superior to that in the control group,the difference being statistically significant(P<0.05).Conclusion The modified Longdan Xiegan Decoction can effectively shorten the duration of clinical symptoms,improve the liver function indexes and increase the scores of quality of life of primary hepatocellular carcinoma patients with embolism syndrome after TACE.And the recipe has good value in clinical use.
作者
李朋娟
赖丽
李红阁
LI Peng-Juan;LAI Li;LI Hortg-Ge(Dept,of Traditional Chinese Medicine,Weinan Central Hospital,Weinan 714000 Shaanxi,China;Preparation Center,Ankang Hospital of Traditional Chinese Medicine,Ankang 725000 Shaanxi,China)
出处
《广州中医药大学学报》
CAS
2021年第5期876-879,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
加减龙胆泻肝汤
原发性肝癌
肝动脉化疗栓塞术(TACE)
术后栓塞综合征
肝经热毒证
肝功能
生活质量
modified Longdan Xiegan Decoction
primary liver cancer
transcatheter arterial chemoembolization(TACE)
postoperative embolism syndrome
syndrome of heat toxin in liver meridian
liver function
quality of life
