摘要
目的确定SARS-CoV-2无症状感染者与COVID-19患者流行病学特征差异。方法提取PubMed、Web of Science、中国知网、维普网、万方数据知识服务平台内SARS-CoV-2无症状传播文献相关数据,截止日期为2020年8月1日。根据预先制定的纳入排除标准筛选和提取流行病学信息。对无症状传播者的年龄、性别、病毒RNA脱落时间及病毒载量等情况进行汇总和分析。结果共38篇文献符合标准,其中17篇文献为无症状感染病毒RNA脱落时间相关病例报告。与有症状感染者相比,无症状感染者更加年轻[加权均数差(weighted mean difference,WMD),WMD=-5.27,95%CI:-9.78~-0.76,P<0.001]、病毒RNA脱落时间(中位数:11 d)较有症状感染者缩短(中位数:16 d)(P<0.001)、上呼吸道拭子核酸载量较低(WMD=2.36,95%CI:0.65~4.07,P=0.007),二者性别组成无统计学差异。结论与COVID-19患者相比,SARS-CoV-2无症状感染者较年轻,病毒载量较低,病毒RNA脱落时间较短。
Objective To determine the differences in the epidemiological characteristics of asymptomatic patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and coronavirus disease 2019(COVID-19)patients.Methods The relevant data of asymptomatic SARS-CoV-2 transmission literature in PubMed,Web of Science,CNKI,VIP medicine and Wanfang medical database were extracted as of August 1,2020.Epidemiological information was screened and extracted according to pre-established inclusion and exclusion criteria.Age,gender,virus shedding duration and virual load of asymptomatic carriers were summarized and analyzed.Results A total of 38 articles met the criteria,17 of which were asymptomatic case reports related to the virus shedding duration.Compared with symptomatic infected persons,asymptomatic individuals were younger[Weighted Mean Difference(WMD),WMD=-5.27,95%CI:-9.78--0.76,P<0.001]and the viral load was lower(WMD=2.36,95%CI:0.65-4.07,P=0.007).The virus shedding duration of asymptomatic individuals(median=11 days)was shorter than symptomatic patients(median=16 days).Conclusion Asymptomatic individuals with SARS-CoV-2 were younger,had a lower viral load and a shorter virus shedding duration than COVID-19 patients.
作者
李子帅
林剑生
蒲蕊
赵岳
陈一凡
曹广文
LI Zi-shuai;LIN Jian-sheng;PU Rui;ZHAO Yue;CHEN Yi-fan;CAO Guang-wen(Department of Epidemiology,Faculty of Naval Medicine,Naval Medical University,Shanghai 200433,China;School of Medicine,Jinan University,Guangzhou 510632,China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2021年第4期445-453,共9页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(82041022)
上海市科学技术委员会科研基金(20JC1410200,20431900404)。
