摘要
目的探究血清广泛型线粒体肌酸激酶(uMtCK)、胎球蛋白A(AHSG)及中性粒细胞相关载脂蛋白(NGAL)水平与胃癌患者临床病理参数及临床预后的关系。方法选取本院消化内科2017年1月至2019年1月收治的85例胃癌患者作为研究组,另选择同期于本院门诊健康体检的志愿者85例作为对照组,酶联免疫吸附试验(ELISA)检测血清uMtCK、AHSG及NGAL水平,分析uMtCK、AHSG及NGAL与胃癌患者临床病理参数的关系;患者随访2~3年,统计研究期间胃癌患者死亡情况,并分为生存组(n=62)和死亡组(n=23);Cox多因素分析uMtCK、AHSG及NGAL水平异常是否为影响胃癌患者预后的危险因素。结果研究组血清u MtCK、AHSG及NGAL水平均高于对照组,差异有统计学意义(P<0.05)。不同年龄、性别、组织类型、Lauren.s分型胃癌患者血清uMtCK、AHSG及NGAL水平比较均差异无统计学意义(P>0.05);不同肿瘤分化程度、TNM分期、浸润深度、淋巴结转移、远处转移、血管侵犯胃癌患者血清uMtCK、AHSG及NGAL水平比较均差异有统计学意义(P<0.05)。存活组胃癌患者血清uMtCK、AHSG及NGAL水平均低于死亡组,差异有统计学意义(P<0.05)。Cox多因素回归分析结果显示,uMtCK、AHSG及NGAL升高为影响胃癌患者预后的独立危险因素。结论胃癌患者血清uMtCK、AHSG及NGAL存在异常升高的情况,且与胃癌进展、转移及不良预后存在密切相关性,检测相关指标水平有助于胃癌患者的诊断和预后评估。
Objective To explore the relationship between the serum levels of extensive mitochondrial creatine kinase(uMtCK),fetuin A(AHSG)and neutrophil-associated apolipoprotein(NGAL)with clinicopathological parameters and clinical prognosis of patients with gastric cancer.Methods Eighty-five patients with gastric cancer admitted to the Department of Gastroenterology,Ganzi Prefecture People.s Hospital,Sichuan Province from January 2017 to January 2019 were selected as the research group,and 85 volunteers who received physical examination in the outpatient clinic of this hospital during the same period were selected as the control group.ELISA was used to detect the serum levels of uMtCK,AHSG,and NGAL,and analyze the relationship between uMtCK,AHSG,and NGAL and clinicopathological parameters of gastric cancer patients;patients were followed up for 2 to 3 years,and the deaths of gastric cancer patients during the study were counted and divided into the survival groups(n=62)and the death group(n=23).Cox multivariate analysis of whether abnormal levels of uMtCK,AHSG and NGAL are the risk factors affecting the prognosis of gastric cancer patients.Results The serum levels of uMtCK,AHSG and NGAL in the study group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in serum uMtCK,AHSG and NGAL levels in patients with gastric cancer of different ages,genders,tissue types and Lauren.s classification(P>0.05).There were statistically significant differences in serum levels of uMtCK,AHSG and NGAL in patients with different tumor differentiation,TNM stages,depth of invasion,lymph node metastasis,distant metastasis,and vascular invasion of gastric cancer(P<0.05).The serum levels of uMtCK,AHSG and NGAL in the survival group were lower than those in the death group,and the difference was statistically significant(P<0.05).Cox multivariate regression analysis showed that the increase of uMtCK,AHSG and NGAL were independent risk factors affecting the prognosis of gastric cancer patients.Conclusion The serum u Mt CK,AHSG,and NGAL levels in patients with gastric cancer are abnormally elevated,and they are closely related to the progression,metastasis and poor prognosis of gastric cancer.The detection of relevant indicator levels is helpful for the diagnosis and prognosis evaluation of gastric cancer patients.
作者
陈瑶
CHEN Yao(Department of Gastroenterology,West China Branch Hospital of Ganzi Tibetan Autonomous Prefecture,Kangding,Sichuan,China,626000)
出处
《分子诊断与治疗杂志》
2021年第5期720-723,727,共5页
Journal of Molecular Diagnostics and Therapy
基金
四川省医学科研课题计划项目(20181163)。
