摘要
目的系统评价慢性乙型肝炎(CHB)患者进展为肝细胞癌(HCC)的危险因素。方法计算机检索CNKI、Wangfang、CBM、VIP、PubMed、Embase、Cochrane、Web of Science八大数据库文献,检索时间为建库至2020年8月,由两名研究员依据预先制定的纳入标准及排除标准独立筛选病例对照研究文献、提取数据和质量评价后,采用RevMan5.3软件进行Meta分析。结果最终纳入病例对照研究文献11篇,其中中文文献8篇,英文文献3篇;病例组为1311例,对照组为11929例,Meta分析结果显示:未抗病毒治疗(OR=4.36)、肝硬化病史(OR=4.33)、HBV DNA>104 UI/mL(OR=4.23)、肝癌家族史(OR=3.08)、饮酒史(OR=2.63)、年龄>40岁(OR=1.17)是进展为HCC的主要危险因素。结论CHB进展为HCC的危险因素众多,需要针对性地对危险因素做出适时干预从而延缓疾病进展。
Objective To systematically evaluate the risk factors of patients with chronic hepatitis B(CHB)progressing to primary liver cancer(HCC),and to provide some clinical basis for preventing the progression of CHB.Methods Eight databases,including CNKI,Wangfang,CBM,VIP,PubMed,Embase,Cochrane,and Web of Science were searched.The retrieval time was from inception to August 2020.Two researchers independently screened the case-control studies according to the pre-determined inclusion criteria and exclusion criteria,extracted the data and evaluated the quality.Then,RevMan5.3 software was used for meta-analysis.Results Eleven case-control studies were included,including 8 in Chinese and 3 in English;a total of 1311 cases were included in the case group and 11929 cases were included in the control group.Meta-analysis showed that no antiviral treatment(OR=4.36),history of liver cirrhosis(OR=4.33),and HBV DNA>104 UI/mL(OR=4.23),family history of liver cancer(OR=3.08),history of drinking(OR=2.63)and age>40(OR=1.17)were the main risk factors for CHB to develop into HCC.Conclusion There are many risk factors for CHB to develop into HCC,which should be timely intervened to delay the disease progression.
作者
雷莎
文国容
金海
庹必光
LEI Sha;WEN Guo-rong;JIN Hai;TUO Bi-guang(Department of Gastroenterology,the Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,CHINA)
出处
《海南医学》
CAS
2021年第10期1332-1337,共6页
Hainan Medical Journal
基金
国家自然科学基金(编号:81960507/H1602)。
