摘要
淋病是由淋病奈瑟菌(淋球菌)感染引起的一种性传播疾病,其流行和蔓延已成为全球公共卫生事业巨大的负担.抗菌药物治疗是目前淋病防治的主要方式,但随着抗菌药物在临床上的广泛应用,淋球菌的耐药性问题日益严重.深入探究淋球菌的耐药机制,对完善其耐药监测体系和调整临床用药方案均有重要意义.本文在回顾近几年淋球菌耐药机制相关研究的基础上,就临床上几种常见抗菌药物耐药机制的最新研究进展进行了综述,旨在为我国淋病防治策略的制定提供依据.
Gonorrhea is a sexually transmitted disease caused by Neisseria gonorrhoeae infection. Its prevalence and spread have become a huge burden on global public health. Antimicrobial therapy is currently the main method for the prevention and treatment of gonorrhea. However, with the widespread use of antibacterial agents in clinical practice, the resistance of N. gonorrhoeae has become an increasingly serious problem. Exploration of the resistance mechanism of N. gonorrhoeae is essential for improving its resistance monitoring system and adjusting the antimicrobial treatment regimens. We reviewed the recent advances in research on the resistance mechanism of N. gonorrhoeae, aiming to provide reference for the prevention and treatment of gonorrhea in China.
作者
张路路
李雅梅
彭俊平
ZHANG LuLu;LI YaMei;PENG JunPing(NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100176,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2021年第4期412-420,共9页
Scientia Sinica(Vitae)
基金
中国医学科学院医学与健康创新工程协同创新团队项目(批准号:2016-I2M-3-021)
重要传染病病原系统生物学研究(批准号:2018PT51009)
重要传染病病原组学研究项目(批准号:2019PT310006)资助。
关键词
淋病
淋病奈瑟菌
抗菌药物
耐药机制
gonorrhea
Neisseria gonorrhoeae
antibacterial agents
mechanism of resistance
