摘要
目的:分析中青年子宫颈癌癌前病变采用巴氏涂片、液基细胞学(TCT)联合检查诊断的临床价值。方法:以2018年10月-2020年7月入院行子宫颈癌癌前病变筛查的1 256例中青年女性为研究对象,所有检查者行TCT检查、巴氏涂片法,以病理检查结果为金标准,观察两种检查结果与病理活检差异,分析两种检查单独及联合用于癌前病变筛查的意义。结果:病理检查阴性1 051例,CINⅠ85例,CINⅡ66例,CINⅢ47例,SCC 7例,巴氏涂片检查阳性246例,阳性率19.59%,与病理结果比较,其中漏诊15例,误诊56例;TCT检查阳性233例,阳性率18.55%,其中漏诊13例,误诊41例;巴氏涂片检查诊断准确率91.96%,敏感度85.37%,特异度93.24%;TCT检查诊断准确率93.63%,敏感度87.32%,特异度94.86%,两种检查方式联合准确率95.38%,敏感度97.07%,特异度95.05%,诊断率联合>TCT>巴氏涂片,特异度联合>TCT>巴氏涂片,敏感度联合>TCT>巴氏涂片。结论:中青年子宫颈癌癌前病变采用巴氏涂片、TCT联合筛查,临床准确率、敏感度、特异性高,利于临床早期开展相关防治措施,确保患者健康。
Objective:To analyze the clinical value of Pap smear and liquid-based cytology (TCT) in the diagnosis of cervical precancerous lesions in young and middle-aged patients.Method:A total of 1 256 young and middle-aged women who were admitted to the hospital from October 2018 to July 2020 for cervical precancerous lesions screening were studied.All the examiners underwent TCT examination and Pap smear.The results of pathological examination were taken as gold standard.The differences between the two examinations and pathological biopsy were observed,the significance of two kinds of examinations for screening precancerous lesions alone or in combination were analyzed.Result:Pathological examination was negative in 1 051 cases,CINⅠ in 85 cases,CINⅡ in 66 cases,CINⅢ in 47 cases,SCC in 7 cases,Pap smear positive in 246 cases,the positive rate was 19.59%.Compared with pathological results,15 cases were missed diagnosis and 56 cases were misdiagnosed.The positive rate of TCT was 18.55% in 233 cases,included 13 cases of missed diagnosis and 41 cases of misdiagnosis.The diagnostic accuracy,sensitivity and specificity of Pap smear were 91.96%,85.37% and 93.24% respectively.The diagnostic accuracy,sensitivity and specificity of TCT were 93.63%,87.32% and 94.86% respectively.The combined accuracy,sensitivity and specificity of the two methods were 95.38%,97.07% and 95.05% respectively.Diagnostic rate combination >TCT > Pap smear,specificity combination >TCT > Pap smear,sensitivity combination >TCT >Pap smear.Conclusion:Pap smear and TCT combined with screening for cervical precancerous lesions in young and middle-aged patients have high clinical accuracy,sensitivity and specificity,which is conducive to early clinical prevention and treatment measures to ensure the health of patients.
作者
林梅英
李伟
程文德
LIN Meiying;LI Wei;CHENG Wende(Longhua District Central Hospital,Shenzhen,Shenzhen 518000,China;不详)
出处
《中外医学研究》
2021年第12期58-60,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
子宫颈癌
筛查
巴氏涂片
癌前病变
液基细胞学
Cervical cancer
Screening
Pap smear
Precancerous lesions
Liquid-based cytology
