摘要
目的:探讨新辅助化疗对进展期胃癌患者肿瘤术前分期、R0手术切除术及3年无病生存率的影响。方法:选取武汉大学中南医院2015年1月-2017年6月接受新辅助化疗+手术治疗、直接手术治疗的进展期胃癌患者各48例,分别纳入观察组与对照组。统计观察组新辅助化疗近期疗效、毒副反应及化疗前后分期情况,同时比较两组手术切除情况及3年生存率。结果:观察组新辅助化疗治疗有效率为72.92%,临床控制率为87.50%;毒副反应方面,3~4级恶心呕吐、白细胞减少发生率分别为6.25%、2.08%。化疗后,观察组分期较化疗前显著下降(P<0.05)。观察组手术R0切除率为89.58%,显著高于对照组的72.92%(P<0.05)。观察组3年总生存率、无病生存率分别为66.67%、60.42%,高于对照组的43.75%、39.58%,差异有统计学意义(P<0.05)。结论:SOX新辅助化疗治疗进展期胃癌安全有效,能明显提高手术R0切除率及患者3年无病生存率。
Objective:To investigate the influences of neoadjuvant chemotherapy on tumor preoperative staging,surgical R0 resection rate and 3-year disease-free survival rate in patients with advanced gastric cancer.Method:A total of 48 patients with advanced gastric cancer who received neoadjuvant chemotherapy combined with surgical treatment and direct surgical treatment in Central South Hospital,Wuhan University from January 2015 and June 2017 were included in the observation group and the control group,respectively.The short-term curative effect,toxic and adverse effects and staging before and after neoadjuvant chemotherapy were statistically analyzed in the observation group.The status of resection and 3-year survival rate were compared between the two groups.Result:The short-term effective rate of neoadjuvant chemotherapy was 72.92% and the clinical control rate was 87.50%.As for side effects,the incidence of grade 3-4 nausea and vomiting,leukopenia were 6.25% and 2.08% respectively.After chemotherapy,the staging of observation group decreased significantly than that before chemotherapy (P<0.05).The surgical R0 resection rate in the observation group (89.58%) was higher than 72.92% in the control group (P<0.05).The 3-year overall survival rate of the observation group was 66.67%,60.42%,which were higher than 43.75%,39.58% of the control group,and the differences were statistically significant (P<0.05).Conclusion:SOX neoadjuvant chemotherapy is safe and effective in the treatment of advanced gastric cancer.It can significantly improve the surgical R0 resection rate and 3-year disease-free survival rate.
作者
黄卫彬
彭晋
洪琳
HUANG Weibin;PENG Jin;HONG Lin(Qichun County People’s Hospital,Qichun 435300,China;不详)
出处
《中外医学研究》
2021年第12期151-153,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
进展期胃癌
新辅助化疗
术前分期
R0切除
随访结果
Advanced gastric cancer
Neoadjuvant chemotherapy
Preoperative staging
R0 resection
Follow-up results
