摘要
目的了解江西地区女性不孕患者生殖道支原体感染特点及药敏情况,为临床合理用药提供指导。方法选取2016年1月~2019年12月就诊于我院的26411例不孕患者作为观察组,另选同期优生优育体检女性7718例作为对照组,取宫颈分泌物进行解脲脲原体(Uu)、人型支原体(Mh)鉴定及药敏试验。比较两组Uu单独感染、Mh单独感染和Uu+Mh混合感染阳性率及两组阳性标本对12种抗菌药物的耐药率。结果不孕组支原体总阳性率、Uu+Mh混合感染率高于对照组,差异有统计学意义(P<0.05);两组Uu、Mh单独感染率比较,差异无统计学意义(P>0.05);生殖道支原体对环丙沙星耐药率最高,其次为红霉素和司巴沙星;对交沙霉素最为敏感,其次为美满霉素、强力霉素和四环素;除以上四种最敏感抗菌药物外,不孕组对各抗菌药物的耐药率均高于对照组,差异有统计学意义(P<0.05)。结论女性不孕患者生殖道支原体感染率较正常育龄妇女更高,主要表现为Uu+Mh混合感染率更高,且对于各抗菌药物耐药率更高。临床治疗时应根据药敏结果选择抗菌药物,其中交沙霉素、美满霉素、强力霉素可作为首选药物。
Objective To understand the characteristics of genital mycoplasma infection and drug sensitivity in female infertile patients in Jiangxi,and provide guidance for clinical rational use of drugs.Methods 26,411 infertile patients who were admitted to our hospital from January 2016 to December 2019 were selected as the observation group.In addition,7718 women with prenatal and postnatal physical examination during the same period were selected as the control group,and the cervical secretions were taken for the identification of Ureaplasma Urealyticum(Uu)and Mycoplasma hominis(Mh)and drug sensitivity test.The positive rates of Uu alone infection,Mh alone infection and Uu+Mh mixed infection between the two groups were compared,and the resistance rates of the two groups of positive specimens to 12 antibacterial drugs were compared.Results The total positive rate of mycoplasma and the mixed infection rate of Uu+Mh in the infertility group were higher than those in the control group,the difference was statistically significant(P<0.05);There was no statistically significant difference in Uu and Mh infection rates between the two groups(P>0.05);Mycoplasma genitalium had the highest resistance rate to ciprofloxacin,followed by erythromycin and sparfloxacin;the most sensitive to josamycin,followed by minocycline,doxycycline and tetracycline;Except for the above four most sensitive antibacterial drugs,the resistance rate of each antibacterial drug in the infertility group was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion The infection rate of mycoplasma in the genital tract of female infertility patients is higher than that of normal women of childbearing age,mainly due to the higher rate of Uu+Mh mixed infection and higher rate of resistance to various antimicrobial drugs.In clinical treatment,antibacterial drugs should be selected according to the results of drug sensitivity,among which josamycin,minocycline,and doxycycline can be the first choice.
作者
汤旭
胡雪莉
邱德稳
TANG Xu;HU Xue-li;QIU De-wen(Department of Laboratory Medicine,Jiangxi Maternal and Child Health Hospital,Nanchang 330000,Jiangxi,China)
出处
《医学信息》
2021年第12期159-161,共3页
Journal of Medical Information
关键词
支原体感染
不孕
耐药性
Mycoplasma infection
Infertility
Drug resistance
