摘要
目的探究老年非ST段抬高型心肌梗死(NSTEMI)并心房颤动(AF)实施不同抗栓治疗方案的疗效及安全性。方法对2017年1月-2019年6月在本院接受抗栓治疗的100例NSTEMI并AF患者进行研究,根据不同治疗方案分为A、B、C、D四组,各25例。A组:华法林;B组:华法林+替格瑞洛;C组:阿司匹林+替格瑞洛;D组:华法林+替格瑞洛+阿司匹林,观察治疗效果。结果治疗后,四组血清肌钙蛋白T(cTnT)、肌酸激酶同工酶(CK-MB)水平均有所降低(P<0.05),且四组间对比差异无统计学意义(P>0.05);D组出血发生率高于A、B、C组(P<0.05),且A、B、C三组间差异无统计学意义(P>0.05);B组血栓栓塞发生率低于A、C组(P<0.05),且D组低于A、C组(P<0.05)。结论不同的抗栓治疗方案在老年NSTEMI并AF中的疗效及安全性存在差异,临床工作中应结合患者的具体病情进行选择。
Objective To study the effects and safety of different antithrombotic therapies in elderly NSETMI(non-ST-segment elevation myocardial infarction)patients with AF(atrial fibrillation).Methods From January 2017 to June 2019,100 elderly NSETMI patients with AF treated in our hospital were investigated.According to different therapies,patients were divided into group A(Warfarin),group B(Warfarin+Ticagrelor),group C(Aspirin+Ticagrelor)and group D(Warfarin+Ticagrelor+Aspirin),25 cases in each group.Therapeutic effects were probed.Results After treatment,cardiac troponin T(cTnT)and creatine kinase-MB(CK-MB)levels for four groups were reduced(P<0.05);no significant differences among four groups were observed(P>0.05);bleeding rate in group D was higher than group A,group B and group C(P<0.05);bleeding rate among group A,group B and group C was not significantly different(P>0.05);incidence of thromboembolism in group B was lower than group A and group C(P<0.05);incidence of thromboembolism in group D was lower than group A and group C(P<0.05).Conclusion Patient’s clinical effects and safety can be varied with different antithrombotic therapies.The proper schemes shall be selected according to their illness states.
作者
汪学东
吴继承
WANG Xuedong;WU Jicheng(Cardiovascular Medicine Department Ezhou Third Hospital,Ezhou Hubei 436099,China;Operating Room Ezhou Third Hospital,Ezhou Hubei 436099,China)
出处
《中国继续医学教育》
2021年第17期165-168,共4页
China Continuing Medical Education
关键词
抗栓治疗
老年
非ST段抬高
心肌梗死
心房颤动
华法林
阿司匹林
antithrombotic therapy
elderly
non-ST-segment elevation
myocardial infarction
atrial fibrillation
warfarin
aspirin
