摘要
目的探讨温阳补肾法治疗骨质疏松性骨折对患者疼痛介质及血清sVCAM-1、PDGF、BGP水平的影响。方法选择骨质疏松性骨折患者106例作为研究对象,通过随机数字表法分为研究组与对照组,各53例。对照组采用常规保守治疗,研究组在对照组的基础上予温阳补肾法进行治疗,2组均治疗3个月。比较2组治疗3个月后的临床疗效;对比2组治疗前、治疗3个月后的骨痂生长评分、中医证候积分、血清疼痛介质及骨代谢指标水平。结果治疗3个月后,研究组总有效率(96.23%,51/53)高于对照组(75.47%,40/53)(P<0.05)。治疗3个月后,2组骨痂生长评分、中医证候积分、血清PGE2、5-HT、NO、sVCAM-1水平较治疗前降低,研究组低于对照组(P<0.05);2组血清PDGF、BGP水平较治疗前升高,研究组高于对照组(P<0.05)。结论温阳补肾法治疗骨质疏松性骨折,可明显降低患者血清疼痛介质水平,减轻疼痛,并能降低血清sVCAM-1水平,升高血清PDGF、BGP水平,促进骨折愈合,有助于提高临床疗效。
Objective To investigate the effect of the warming yang and tonifying kidney therapy on the pain mediators and the levels of serums of sVCAM-1,PDGF and BGP in patients with osteoporotic fracture.Methods A total of 106 patients with osteoporotic fracture were selected as the research subjects,and they were divided into the study group and the control group by random number table method,with 53 cases in each group.The control group was treated with the conventional conservative treatment,and the study group was treated with the warming yang and tonifying kidney therapy on the basis of the control group.Both groups were treated for 3 months.The clinical efficacy of the two groups were compared after 3 months of treatment.The callus growth score,TCM syndrome score,levels of the serum pain mediators and bone metabolism indexes of the two groups were compared before and 3 months after treatment.Results After 3 months of treatment,the total effective rate of the study group(96.23%,51/53)was higher than that of the control group(75.47%,40/53)(P<0.05).After 3 months of treatment,the callus growth score,TCM syndrome score,levels of the serums of PGE2,5-HT,NO,and sVCAM-1 in the 2 groups were lower than before treatment,and the study group was lower than the control group(P<0.05).The serum levels of PDGF and BGP in the two groups were higher than those before treatment,and those in the study group were higher than those in the control group(P<0.05).Conclusion The warming yang and tonifying kidney therapy in the treatment of osteoporotic fracture can significantly reduce the patients’level of the serum pain mediators,relieve pain,reduce the level of serum sVCAM-1,increase the levels of the serums of PDGF and BGP,promote fracture healing,and help improve the clinical efficacy.
作者
陈康耀
江涛
黄永铨
陈善创
苏海涛
CHEN Kangyao;JIANG Tao;HUANG Yongquan;CHEN Shanchuang;SU Haitao(The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Department of Orthopedics,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510006,China)
出处
《长春中医药大学学报》
2021年第3期598-601,共4页
Journal of Changchun University of Chinese Medicine
关键词
骨质疏松症
骨折
温阳补肾法
疼痛介质
osteoporosis
fracture
warming yang and tonifying kidney therapy
pain mediator
