摘要
目的探讨丹参川芎嗪注射液对脑血栓患者NIHSS评分及血流变化指标的影响。方法选取2017年1月至2019年1月本院收治的109例脑血栓患者作为研究对象,采用随机数表法分为对照组(n=54)与观察组(n=55)。两组均给予常规治疗,对照组在常规治疗基础上采用低分子肝素钙治疗,观察组在常规治疗基础上采用丹参川芎嗪治疗。比较两组治疗后美国国立卫生院神经功能缺损量表(NIHSS)评分、血流变化指标及血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、丙二醛(MDA)水平变化。结果治疗后,两组NIHSS评分均降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组全血高切黏度、血浆比黏度、全血低切黏度、纤维蛋白原含量均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清IL-6、TNF-α、MDA水平均低于对照组,差异有统计学意义(P<0.05)。结论丹参川芎嗪注射液治疗脑血栓患者效果显著,能有效减轻神经功能损伤,降低炎症反应,改善血液流变学,值得临床推广应用。
Objective To investigate the effect of salvia miltiorrhiza ligustrazine injection on NIHSS score and blood flow in patients with cerebral thrombosis.Methods 109 patients with cerebral thrombosis from January 2017 to January 2019 admitted in our hospital were selected as research subjects,they were divided into control group(n=54)and observation group(n=55)according to the random number table method.Both groups were given routine treatment,the control group was treated with low molecular weight heparin calcium,the observation group was treated with salvia miltiorrhiza ligustrazine on the basis of routine treatment.The scores of the National Institutes of Health Neurological Impairment Scale(NIHSS),blood flow changes and serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and malondialdehyde(MDA)were compared between the two groups after treatment.Results After treatment,the NIHSS scores of the two groups were reduced,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After treatment,the whole blood viscosity,plasma viscosity,whole blood viscosity and fibrin content in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).After treatment,the serum IL-6,TNF-α,MDA levels in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion Salvia miltiorrhiza ligustrazine injection is effective in treating cerebral thrombosis,can effectively reduce nerve function damage,decrease inflammation,improve hemorheology,it is worthy of clinical application.
作者
李赛梅
LI Saimei(Department of Pharmacy,the Second People's Hospital and Gynecology and Obstetrics Hospital of Fuxin City,Liaoning Province,Fuxin,Liaoning,123000,China)
出处
《当代医学》
2021年第17期89-91,共3页
Contemporary Medicine
关键词
脑血栓
丹参川芎嗪
神经功能
血液流变学
Cerebral thrombosis
Salvia miltiorrhiza ligustrazine
Nerve function
Hemorheology
