摘要
目的研究不同表面包覆剂对当归超微粉的包覆效果,优选最佳的当归超微粉表面包覆稳定性技术。方法以均匀度为指标,优选不同表面包覆剂的包覆比例,并在此基础上,以水分、挥发油、阿魏酸、洋川芎内酯I和藁本内酯为指标,采用长期稳定性试验的考察方法,考察在不同的包覆剂条件下,当归表面包覆超微粉在24个月内的质量变化情况,优选最佳的包覆条件。结果确定了不同表面包覆剂的最佳包覆比例为,微粉:药用二氧化硅(4∶1)、微粉∶食用淀粉(3∶1)、微粉:β-环糊精(3∶1)。通过长期稳定性考察可知,当归超微粉表面包覆能有效得降低下降速率,其中β-环糊精效果较好。因此,最终优选的最佳包覆条件为,微粉∶β-环糊精(3∶1)。结论当归作为常用的药食两用品种,临床和食疗应用广泛,表面包覆技术对减缓当归微粉的成分损失具有明显的效果,从而为当归微粉产品开发提供了一定的技术支持。
OBJECTIVE Study on the coating effect of different surface coating agents on Angelicae Sinensis radix ultrafine powder,to optimize the optimal Angelicae Sinensis radix ultrafine powder surface coating process.METHODS Using uniformity as an index,the coating ratio of different surface coating agents is preferred,and on this basis,moisture,volatile oil,ferulic acid,yangchuan lactone I,and ligustilide are used as indicators.The method of investigation is to examine the quality change of Angelicae Sinensis radix surface coated ultrafine powder within 24 months under different coating agent conditions,and the optimal coating conditions are preferred.RESULTS The best coating ratios of different surface coating agents were determined as follows:micronized powder∶medicinal silica(4∶1),micronized powder∶edible starch(3∶1),micronized powder∶β-cyclodextrin(3∶1).It can be known from long-term stability investigation that the surface coating of Angelicae Sinensis radix ultrafine powder can effectively reduce the decline rate,andβ-cyclodextrin has a better effect.Therefore,the final optimal coating conditions are∶fine powder∶β-cyclodextrin(3∶1).CONCLUSION Angelicae sinensis radix as a commonly used dual-use medicinal and edible variety has a wide range of clinical and dietary applications.The surface coating technology has a significant effect on slowing down the component loss of Angelicae Sinensis radix micropowder,thus providing certain technical support for the development of Angelicae Sinensis radix micropowder product.
作者
张洪坤
郭长达
黄玉瑶
路丽
高贯彪
ZHANG Hongkun;GUO Changda;HUANG Yuyao;LU li;GAO Guanbiao(Bozhou Huqiao Pharmaceutical Industy Limited Company,Bozhou,Anhui 236800,China;Guangzhou Zhongzhiyuan Chinese MedicineCo.,Ltd,Guangzhou,Guangdong 510925,China)
出处
《今日药学》
CAS
2021年第4期284-289,共6页
Pharmacy Today
基金
安徽省科技重大专项(18030801119)
国家中医药管理局中药标准化项目(ZYBZH-Y-AH-03)。
关键词
当归
超微粉
表面包覆
工艺
长期稳定性
Angelicae Sinensis radix
ultrafine powder
surface coating
craft
long-term stability
